英国生物银行中植物性饮食的质量与肝癌发病率和肝病死亡率的关系

IF 2.6 Q3 NUTRITION & DIETETICS Clinical nutrition ESPEN Pub Date : 2025-04-03 DOI:10.1016/j.clnesp.2025.03.166

Xiaocong Dong , Mingjie Zhang , Jing Shu , Yunshan Li , Peishan Tan , Tianyou Peng , Jialin Lu , Yaojun Zhang , Xiali Zhong , Aiping Fang

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引用次数: 0

摘要

背景与目的：植物性饮食与各种慢性疾病的风险较低有关。然而，它们在预防肝癌和肝脏相关死亡中的作用目前尚不清楚。我们的目的是在英国生物银行中调查植物性饮食与肝癌发病率和肝病死亡率之间的关系。方法：我们从英国生物银行中纳入了85,810名男性和101,971名女性。三个植物性饮食指数，包括总体植物性饮食指数（PDI），健康植物性饮食指数（hPDI）和不健康植物性饮食指数（uPDI），基于17种食物组，使用至少一次24小时饮食评估的数据创建。Cox比例风险模型用于估计多变量调整风险比（hr）和95%置信区间（ci）。结果：随访期间，男性109人，女性68人，男性190人，女性108人死于肝脏疾病。总体PDI评分与男性或女性的肝癌发病率或肝病死亡率无关。然而，较高的hPDI评分与较低的肝癌发病率相关(HRQ5 vs. Q1: 0.47；95%ci: 0.26, 0.85；p趋势=0.005)和肝病死亡率(HRQ5 vs. Q1: 0.46；95%ci: 0.27, 0.77；P-trend=0.011)。较高的uPDI评分与肝癌发病率增加相关(HRQ5 vs. Q1: 1.90；95%ci: 1.00, 3,63；P-trend=0.038)和肝脏疾病相关死亡风险较高(HRQ5 vs. Q1: 2.21；95%ci: 1.37, 3.57；p趋势结论：我们的研究结果表明，更坚持植物性饮食，强调健康的植物性食物，同时限制不健康的植物性食物，可能可以预防男性肝癌和肝脏疾病相关的死亡，但对女性没有作用。

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The quality of plant-based diets and liver cancer incidence and liver disease mortality in the UK Biobank

Background & aims

Plant-based diets have been associated with a lower risk of various chronic diseases. However, their role in preventing liver cancer and liver-related death is currently unclear. We aimed to investigate the association between plant-based diets and the risk of liver cancer incidence and liver disease mortality in the UK Biobank.

Methods

We included 85,810 males and 101,971 females from the UK Biobank in our analyses. Three plant-based diet indices, including an overall plant-based diet index (PDI), a healthful plant-based diet index (hPDI), and an unhealthful plant-based diet index (uPDI), were created based on 17 food groups using data from at least one 24-hour dietary assessments. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

During follow-up, 109 males and 68 females developed liver cancer, and 190 males and 108 females died from liver diseases. Overall PDI scores were not associated with liver cancer incidence or liver disease mortality in either males or females. However, higher hPDI scores were linked to a lower risk of liver cancer incidence (HR_{Q5 vs. Q1}: 0.47; 95%CI: 0.26, 0.85; P-trend=0.005) and liver disease mortality (HR_{Q5 vs. Q1}: 0.46; 95%CI: 0.27, 0.77; P-trend=0.011) in males. Higher uPDI scores were associated with an increased incidence of liver cancer (HR_{Q5 vs. Q1}: 1.90; 95%CI: 1.00, 3,63; P-trend=0.038) and a higher risk of liver disease-related deaths (HR_{Q5 vs. Q1}: 2.21; 95%CI: 1.37, 3.57; P-trend <0.001). However, no such associations between hPDI or uPDI and the risk of liver cancer or liver disease mortality were observed in females.

Conclusions

Our results suggest that higher adherence to plant-based diets, emphasizing healthful plant-based foods while restricting less healthful plant foods, may protect against liver cancer and liver disease-related deaths in males, but not in females.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.