{"title":"脐带间充质干细胞治疗缺血性脑卒中动物模型的疗效及其潜在机制：荟萃分析","authors":"Renli Wei, Minguang Yang, Yue Cao, Shuqian Qiu, Xu Fan, Muxuan Fang, Li Chen, Shaojie Cheng, Jianhong Li, Shenghang Zhang","doi":"10.1111/cns.70357","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Umbilical cord-derived mesenchymal stem cells (UCMSCs) have emerged as a promising treatment for ischemic stroke. This study aimed to evaluate the therapeutic efficacy and potential mechanisms of UCMSCs in treating ischemic stroke.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A systematic search of PubMed, Web of Science, and Embase was conducted up to April 25, 2024. Literature was screened based on the PICOS principle, with predefined inclusion and exclusion criteria. Relevant data were extracted and analyzed using Review Manager 5.4.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Out of 1390 retrieved articles, 30 were included in the meta-analysis. UCMSCs significantly reduced infarct size and volume, improved neurological deficit scores, and facilitated neurobehavioral recovery. UCMSCs treatment also modulated inflammatory cytokine levels in brain tissue and serum, promoted microglial polarization, inhibited apoptosis, and increased vessel density in the peri-infarct tissue.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>UCMSCs administration significantly promoted the neurological function recovery after ischemic stroke. Their mechanisms of action may be related to immune response regulation, inhibition of apoptosis, and promotion of angiogenesis. These findings provide theoretical guidance for improving the quality of basic research and clinical translation.</p>\n </section>\n </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 4","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70357","citationCount":"0","resultStr":"{\"title\":\"Efficacy and Potential Mechanisms of Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Ischemic Stroke in Animal Models: A Meta-Analysis\",\"authors\":\"Renli Wei, Minguang Yang, Yue Cao, Shuqian Qiu, Xu Fan, Muxuan Fang, Li Chen, Shaojie Cheng, Jianhong Li, Shenghang Zhang\",\"doi\":\"10.1111/cns.70357\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Umbilical cord-derived mesenchymal stem cells (UCMSCs) have emerged as a promising treatment for ischemic stroke. 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引用次数: 0
摘要
脐带间充质干细胞（UCMSCs）已成为一种有希望的缺血性卒中治疗方法。本研究旨在评价UCMSCs治疗缺血性脑卒中的疗效及其潜在机制。方法系统检索截至2024年4月25日的PubMed、Web of Science、Embase数据库。根据PICOS原则筛选文献，并预先确定纳入和排除标准。使用Review Manager 5.4提取相关数据并进行分析。在1390篇检索文章中，30篇被纳入meta分析。UCMSCs显著减少梗死面积和体积，改善神经功能缺损评分，促进神经行为恢复。UCMSCs处理还可以调节脑组织和血清中的炎症细胞因子水平，促进小胶质细胞极化，抑制细胞凋亡，增加梗死周围组织的血管密度。结论给药UCMSCs可显著促进缺血性脑卒中后神经功能的恢复。其作用机制可能与调节免疫应答、抑制细胞凋亡、促进血管生成有关。这些发现为提高基础研究质量和临床转译提供了理论指导。
Efficacy and Potential Mechanisms of Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Ischemic Stroke in Animal Models: A Meta-Analysis
Background
Umbilical cord-derived mesenchymal stem cells (UCMSCs) have emerged as a promising treatment for ischemic stroke. This study aimed to evaluate the therapeutic efficacy and potential mechanisms of UCMSCs in treating ischemic stroke.
Methods
A systematic search of PubMed, Web of Science, and Embase was conducted up to April 25, 2024. Literature was screened based on the PICOS principle, with predefined inclusion and exclusion criteria. Relevant data were extracted and analyzed using Review Manager 5.4.
Results
Out of 1390 retrieved articles, 30 were included in the meta-analysis. UCMSCs significantly reduced infarct size and volume, improved neurological deficit scores, and facilitated neurobehavioral recovery. UCMSCs treatment also modulated inflammatory cytokine levels in brain tissue and serum, promoted microglial polarization, inhibited apoptosis, and increased vessel density in the peri-infarct tissue.
Conclusions
UCMSCs administration significantly promoted the neurological function recovery after ischemic stroke. Their mechanisms of action may be related to immune response regulation, inhibition of apoptosis, and promotion of angiogenesis. These findings provide theoretical guidance for improving the quality of basic research and clinical translation.
期刊介绍：
CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.
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