[2.2]Paracyclophane-substituted quinolines by skeletal editing strategies†

The synthesis of 2- and 3-substituted [2.2]paracyclophanyl quinolines using two distinct skeletal editing strategies is described. The first approach relies on indole ring expansion and furnishes 3-aryl quinolines with the paracyclophanyl substituent in the 2-position. In contrast, the second uses a paracyclophane-derived carbene precursor and delivers the complementary 3-[2.2]paracyclophanyl quinolines, highlighting skeletal editing as a powerful tool for advancing the synthetic chemistry of [2.2]paracyclophanes.