反式-1,2-二氯乙烯选择性偶联合成绿质素A和B

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC Journal of Organic Chemistry Pub Date : 2025-04-14 DOI:10.1021/acs.joc.4c02975

Feddro Gilbert Wijaya, Sopan Pralhad Khandare, Dániel Csókás, Raghunath O. Ramabhadran, Roderick W. Bates

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引用次数: 0

摘要

采用Suzuki偶联法和反式-1,2-二氯乙烯Heck反应，先后合成了(−)-病毒素A和(−)-病毒素B。反式-1,2-二氯乙烯单偶联的选择性归因于氧化加成步骤的低能过渡态。

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Synthesis of Viriditins A and B by Selective Coupling of Trans-1,2-Dichloroethylene

A synthesis of (−)-viriditin A and (−)-viriditin B has been completed sequentially using a Suzuki coupling and a Heck reaction of trans-1,2-dichloroethylene. The selectivity for monocoupling of trans-1,2-dichloroethylene is attributed to a lower-energy transition state for the oxidative addition step.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.