脲嘧啶甲素A结构的合成

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2025-04-20 DOI:10.1021/acs.orglett.5c01046

Takuya Tsukamoto, Keisuke Takahashi, Kyoka Someya, Taichi Kusakabe, Keisuke Kato

引用次数: 0

摘要

合成了所提出的脲嘧啶甲素的结构。通过Pd（II）催化无环丙炔胍的环化-羰基化-环化级联反应构建了双环胍核。n -羟基胍的功能被保护为THP醚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of the Proposed Structure of Urupocidin A

The proposed structure of urupocidin A was synthesized. The bicyclic guanidino core was constructed by Pd(II) catalyzed cyclization-carbonylation-cyclization cascade reactions of the acyclic propargyl guanidine. The N-hydroxy guanidino functionality was protected as a THP ether.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.