{"title":"儿童室内环境中粉尘的内分泌干扰潜力：与用于健康风险评估的不同化合物类别的多种化学物质的关联","authors":"Ylva Sjöström , Breanne Holmes , Niklas Ricklund , Nathalie Struwe , Katja Hagström , Jessika Hagberg , Maria Larsson","doi":"10.1016/j.envres.2025.121614","DOIUrl":null,"url":null,"abstract":"<div><div>Indoor dust contains a complex mixture of chemicals, including endocrine-disrupting chemicals (EDCs), which may pose risks to children's health. As children spend most of their time indoors and have frequent dust contact, their exposure is heightened. This study quantified the endocrine disrupting potential of dust from children's indoor environments in Sweden, and assessed associations with flame retardants and plasticizers in dust, handwipes, and urine.</div><div>Fifty dust samples from 18 homes and 11 preschool units were analyzed for estrogen, anti-androgen, and thyroid receptor activities using human osteosarcoma cell-based luciferase reporter assays. Associations were evaluated with 21 legacy and 18 emerging halogenated flame retardants (HFRs) and 11 organophosphate esters (OPEs) in dust and handwipes, as well as nine plasticizers (eight phthalates and di-isononyl cyclohexane 1,2-dicarboxylate (DiNCH)) in dust, and 14 plasticizer metabolites in urine. Samples for biological and chemical analyses were collected from the same designated areas within a limited time frame.</div><div>Most dust samples exhibited estrogen receptor agonist (ER) and androgen receptor antagonistic (anti-AR) activity, while thyroid receptor (TR) induction was low. Preschool dust showed significantly higher estrogenic activity than home dust. No seasonal variation was observed. Associations were observed between dust hormonal activities and urinary plasticizer metabolites, as well as HFR and OPE concentrations in dust and handwipes. Relative potency (REP) analyses of 36 HFRs and OPEs revealed notable anti-AR activity for 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) (REP values .85 ± .10 (EC25) and .93 ± .07 (EC50)) and 2,2′,4,4′,6-pentabromo diphenyl ether (BDE-100) (REP values 2.74 ± .29 (EC25) and 3.23 ± .42 (EC50)). Additionally, BDE-100 showed low ER induction.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"278 ","pages":"Article 121614"},"PeriodicalIF":8.2000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Endocrine disruption potential of dust in children's indoor environments: Associations with multiple chemicals from various compound classes across exposure matrices used for health risk assessment\",\"authors\":\"Ylva Sjöström , Breanne Holmes , Niklas Ricklund , Nathalie Struwe , Katja Hagström , Jessika Hagberg , Maria Larsson\",\"doi\":\"10.1016/j.envres.2025.121614\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Indoor dust contains a complex mixture of chemicals, including endocrine-disrupting chemicals (EDCs), which may pose risks to children's health. As children spend most of their time indoors and have frequent dust contact, their exposure is heightened. This study quantified the endocrine disrupting potential of dust from children's indoor environments in Sweden, and assessed associations with flame retardants and plasticizers in dust, handwipes, and urine.</div><div>Fifty dust samples from 18 homes and 11 preschool units were analyzed for estrogen, anti-androgen, and thyroid receptor activities using human osteosarcoma cell-based luciferase reporter assays. Associations were evaluated with 21 legacy and 18 emerging halogenated flame retardants (HFRs) and 11 organophosphate esters (OPEs) in dust and handwipes, as well as nine plasticizers (eight phthalates and di-isononyl cyclohexane 1,2-dicarboxylate (DiNCH)) in dust, and 14 plasticizer metabolites in urine. Samples for biological and chemical analyses were collected from the same designated areas within a limited time frame.</div><div>Most dust samples exhibited estrogen receptor agonist (ER) and androgen receptor antagonistic (anti-AR) activity, while thyroid receptor (TR) induction was low. Preschool dust showed significantly higher estrogenic activity than home dust. No seasonal variation was observed. Associations were observed between dust hormonal activities and urinary plasticizer metabolites, as well as HFR and OPE concentrations in dust and handwipes. Relative potency (REP) analyses of 36 HFRs and OPEs revealed notable anti-AR activity for 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) (REP values .85 ± .10 (EC25) and .93 ± .07 (EC50)) and 2,2′,4,4′,6-pentabromo diphenyl ether (BDE-100) (REP values 2.74 ± .29 (EC25) and 3.23 ± .42 (EC50)). Additionally, BDE-100 showed low ER induction.</div></div>\",\"PeriodicalId\":312,\"journal\":{\"name\":\"Environmental Research\",\"volume\":\"278 \",\"pages\":\"Article 121614\"},\"PeriodicalIF\":8.2000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Research\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0013935125008655\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Research","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0013935125008655","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/17 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Endocrine disruption potential of dust in children's indoor environments: Associations with multiple chemicals from various compound classes across exposure matrices used for health risk assessment
Indoor dust contains a complex mixture of chemicals, including endocrine-disrupting chemicals (EDCs), which may pose risks to children's health. As children spend most of their time indoors and have frequent dust contact, their exposure is heightened. This study quantified the endocrine disrupting potential of dust from children's indoor environments in Sweden, and assessed associations with flame retardants and plasticizers in dust, handwipes, and urine.
Fifty dust samples from 18 homes and 11 preschool units were analyzed for estrogen, anti-androgen, and thyroid receptor activities using human osteosarcoma cell-based luciferase reporter assays. Associations were evaluated with 21 legacy and 18 emerging halogenated flame retardants (HFRs) and 11 organophosphate esters (OPEs) in dust and handwipes, as well as nine plasticizers (eight phthalates and di-isononyl cyclohexane 1,2-dicarboxylate (DiNCH)) in dust, and 14 plasticizer metabolites in urine. Samples for biological and chemical analyses were collected from the same designated areas within a limited time frame.
Most dust samples exhibited estrogen receptor agonist (ER) and androgen receptor antagonistic (anti-AR) activity, while thyroid receptor (TR) induction was low. Preschool dust showed significantly higher estrogenic activity than home dust. No seasonal variation was observed. Associations were observed between dust hormonal activities and urinary plasticizer metabolites, as well as HFR and OPE concentrations in dust and handwipes. Relative potency (REP) analyses of 36 HFRs and OPEs revealed notable anti-AR activity for 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) (REP values .85 ± .10 (EC25) and .93 ± .07 (EC50)) and 2,2′,4,4′,6-pentabromo diphenyl ether (BDE-100) (REP values 2.74 ± .29 (EC25) and 3.23 ± .42 (EC50)). Additionally, BDE-100 showed low ER induction.
期刊介绍：
The Environmental Research journal presents a broad range of interdisciplinary research, focused on addressing worldwide environmental concerns and featuring innovative findings. Our publication strives to explore relevant anthropogenic issues across various environmental sectors, showcasing practical applications in real-life settings.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
