{"title":"[低分子量半抗原载体化学结构对免疫反应性的影响]。","authors":"G Schwartze, D Lübbe, K D Wozniak","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Patients with demonstrated contact dermatitis to DNCB (dinitrochlorobenzene) were patch-tested using various dinitrophenyl (DNP) derivatives. These investigations revealed the varying sensitivities to the structural isomers DNP-L-alpha-alanine (59% positive) and DNP-beta-alanine (4% positive). These results are discussed both in connection with various sensitivity rates to other DNP compounds and published findings from the literature concerning the influence of structural factors on immune reactivity.</p>","PeriodicalId":11073,"journal":{"name":"Dermatosen in Beruf und Umwelt. Occupation and environment","volume":"36 2","pages":"58-60"},"PeriodicalIF":0.0000,"publicationDate":"1988-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Effect of the chemical structure of low molecular weight hapten carriers on immunoreactivity].\",\"authors\":\"G Schwartze, D Lübbe, K D Wozniak\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Patients with demonstrated contact dermatitis to DNCB (dinitrochlorobenzene) were patch-tested using various dinitrophenyl (DNP) derivatives. These investigations revealed the varying sensitivities to the structural isomers DNP-L-alpha-alanine (59% positive) and DNP-beta-alanine (4% positive). These results are discussed both in connection with various sensitivity rates to other DNP compounds and published findings from the literature concerning the influence of structural factors on immune reactivity.</p>\",\"PeriodicalId\":11073,\"journal\":{\"name\":\"Dermatosen in Beruf und Umwelt. Occupation and environment\",\"volume\":\"36 2\",\"pages\":\"58-60\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatosen in Beruf und Umwelt. Occupation and environment\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatosen in Beruf und Umwelt. Occupation and environment","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
使用各种二硝基苯(DNP)衍生物对表现为接触性皮炎的DNCB(二硝基苯)患者进行斑贴试验。这些研究揭示了对dnp - l - α -丙氨酸(59%阳性)和dnp - β -丙氨酸(4%阳性)结构异构体的不同敏感性。这些结果讨论了对其他DNP化合物的不同敏感性，以及从文献中发表的关于结构因素对免疫反应性影响的发现。
[Effect of the chemical structure of low molecular weight hapten carriers on immunoreactivity].
Patients with demonstrated contact dermatitis to DNCB (dinitrochlorobenzene) were patch-tested using various dinitrophenyl (DNP) derivatives. These investigations revealed the varying sensitivities to the structural isomers DNP-L-alpha-alanine (59% positive) and DNP-beta-alanine (4% positive). These results are discussed both in connection with various sensitivity rates to other DNP compounds and published findings from the literature concerning the influence of structural factors on immune reactivity.
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