大鼠对可乐定、哌唑嗪和育亨宾脑电反应的年龄相关性变化。

Medical biology Pub Date : 1987-01-01

C Sebban, B Tesolin, A Shvaloff, K Le Roch, P Berthaux

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引用次数: 0

摘要

比较8、22月龄大鼠腹腔注射可乐定、普唑嗪和育亨宾对脑电图的影响。可乐定(0.01 mg/kg)和吡唑嗪(1 mg/kg)提高了光谱功率，育亨宾(0.5 mg/kg)降低了光谱功率。在老年大鼠中，哌唑嗪和育亨宾的脑电图变化较小，但可乐定的脑电图变化较大。这些发现表明，α受体介导的对脑电图的影响随着年龄的增长而改变，并表明量化的脑电图显示了神经递质系统功能状态的年龄相关变化。

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Age-related variation of EEG responses to clonidine, prazosin and yohimbine in rats.

The EEG-effects induced by intraperitoneal administration of clonidine, prazosin and yohimbine to 8 and 22 month old rats were compared. Clonidine (0.01 mg/kg) and prazosin (1 mg/kg) increased spectral powers, yohimbine (0.5 mg/kg) decreased them. In the older rats, EEG variations were smaller for prazosin and yohimbine, but larger for clonidine. These findings show that alpha receptor mediated influences on EEG are changed during aging and show that quantified EEG gives a picture of age related changes in the functional state of the neurotransmitter systems.

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Medical biology

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