{"title":"一种有效的凝血酶抑制剂刺激了未加工茶叶中血小板血栓素的形成","authors":"M. Ali, M. Afzal","doi":"10.1016/0262-1746(87)90055-2","DOIUrl":null,"url":null,"abstract":"<div><p>A ninhydrin positive compound (L2) from commercially available unfermented dry green tea (Thea sinesis) leaves is found to be a potent inhibitor of thrombin-stimulated thromboxane formation in rabbit whole blood. Its potency is compared with caffeine, a member of the methylxanthines family. Both caffeine and L2 inhibit thromboxane formation in whole blood in a dose dependent fashion. L2 inhibition when calculated as I<sub>50</sub>by a dose response curve is found to be more than 40 fold stronger tan caffeine as an inhibitor of thromboxane formation.</p><p>A concentration of L2 as low as 50 μM, supresses thromboxane formation (by 84%) whereas a concentration of 5000 u M is necessary to achieve the same inhibiton with caffeine. The potent inhibitory effect of L2 on the TXB<sub>2</sub> production maybe of benefit in the treatment of vascular disease.</p></div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90055-2","citationCount":"18","resultStr":"{\"title\":\"A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea\",\"authors\":\"M. Ali, M. Afzal\",\"doi\":\"10.1016/0262-1746(87)90055-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A ninhydrin positive compound (L2) from commercially available unfermented dry green tea (Thea sinesis) leaves is found to be a potent inhibitor of thrombin-stimulated thromboxane formation in rabbit whole blood. Its potency is compared with caffeine, a member of the methylxanthines family. Both caffeine and L2 inhibit thromboxane formation in whole blood in a dose dependent fashion. L2 inhibition when calculated as I<sub>50</sub>by a dose response curve is found to be more than 40 fold stronger tan caffeine as an inhibitor of thromboxane formation.</p><p>A concentration of L2 as low as 50 μM, supresses thromboxane formation (by 84%) whereas a concentration of 5000 u M is necessary to achieve the same inhibiton with caffeine. The potent inhibitory effect of L2 on the TXB<sub>2</sub> production maybe of benefit in the treatment of vascular disease.</p></div>\",\"PeriodicalId\":20720,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0262-1746(87)90055-2\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0262174687900552\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0262174687900552","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea
A ninhydrin positive compound (L2) from commercially available unfermented dry green tea (Thea sinesis) leaves is found to be a potent inhibitor of thrombin-stimulated thromboxane formation in rabbit whole blood. Its potency is compared with caffeine, a member of the methylxanthines family. Both caffeine and L2 inhibit thromboxane formation in whole blood in a dose dependent fashion. L2 inhibition when calculated as I50by a dose response curve is found to be more than 40 fold stronger tan caffeine as an inhibitor of thromboxane formation.
A concentration of L2 as low as 50 μM, supresses thromboxane formation (by 84%) whereas a concentration of 5000 u M is necessary to achieve the same inhibiton with caffeine. The potent inhibitory effect of L2 on the TXB2 production maybe of benefit in the treatment of vascular disease.
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