A low protein-high linoleate diet increases glomerular PGE2 and protects renal function in rats with reduced renal mass

Renal function deteriorates progressively in partially nephrectomized rats. This deterioration of renal function may be ameliorated by a diet either low in protein or high in linoleic acid. In the present experiment, partially nephrectomized rats were pair fed diets low in protein, high in linoleic acid or both low in protein and high in linoleic acid. Survival of renal function was most prolonged in rats fed a diet with both a low protein and high linoleic acid content; glomeruli from these animals demonstrated increased glomerular PGE₂ production. This additive effect may be mediated by increased production of the vasodilatory PGE₂ by glomeruli.