Hisayuki Tanizawa, Tomoaki Iwanaga, Hsin-Hsiung Tai
{"title":"吸烟导致大鼠支气管肺泡液中血栓素B2增加，前列腺素E2和6-酮前列腺素F1α释放减少","authors":"Hisayuki Tanizawa, Tomoaki Iwanaga, Hsin-Hsiung Tai","doi":"10.1016/0262-1746(87)90163-6","DOIUrl":null,"url":null,"abstract":"<div><p>Rats were exposed to cigarette smoke once daily for 4 to 8 weeks. Bronchoalveolar lavage fluid was obtained from each animal and assayed for immunoreactive PGE<sub>2</sub>, TXB<sub>2</sub> and 6-Keto-PGF<sub>1α</sub>.Significant increase in TXB<sub>2</sub> and decrease in PGE<sub>2</sub> and 6-Keto-PGF<sub>1α</sub> release into bronchoalveolar fluid as a consequence of cigarette smoking were observed. These changes of arachidonate metabolites in lung alveoli may account in part for bronchoconstriction induced by cigarette smoking.</p></div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90163-6","citationCount":"9","resultStr":"{\"title\":\"Increase in thromboxane B2 and decrease in prostaglandin E2 and 6-ketoprostaglandin F1α release into rat bronchoalveolar fluid as a consequence of cigarette smoking\",\"authors\":\"Hisayuki Tanizawa, Tomoaki Iwanaga, Hsin-Hsiung Tai\",\"doi\":\"10.1016/0262-1746(87)90163-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Rats were exposed to cigarette smoke once daily for 4 to 8 weeks. Bronchoalveolar lavage fluid was obtained from each animal and assayed for immunoreactive PGE<sub>2</sub>, TXB<sub>2</sub> and 6-Keto-PGF<sub>1α</sub>.Significant increase in TXB<sub>2</sub> and decrease in PGE<sub>2</sub> and 6-Keto-PGF<sub>1α</sub> release into bronchoalveolar fluid as a consequence of cigarette smoking were observed. These changes of arachidonate metabolites in lung alveoli may account in part for bronchoconstriction induced by cigarette smoking.</p></div>\",\"PeriodicalId\":20720,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0262-1746(87)90163-6\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0262174687901636\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0262174687901636","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Increase in thromboxane B2 and decrease in prostaglandin E2 and 6-ketoprostaglandin F1α release into rat bronchoalveolar fluid as a consequence of cigarette smoking
Rats were exposed to cigarette smoke once daily for 4 to 8 weeks. Bronchoalveolar lavage fluid was obtained from each animal and assayed for immunoreactive PGE2, TXB2 and 6-Keto-PGF1α.Significant increase in TXB2 and decrease in PGE2 and 6-Keto-PGF1α release into bronchoalveolar fluid as a consequence of cigarette smoking were observed. These changes of arachidonate metabolites in lung alveoli may account in part for bronchoconstriction induced by cigarette smoking.
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