11个欧洲中心尿液收集完整性的多中心研究。1 .用肌酸酐和4-氨基苯甲酸作为标本收集完整性标志存在的一些问题。

Human nutrition. Clinical nutrition Pub Date : 1986-05-01
J T Knuiman, J G Hautvast, L van der Heyden, J Geboers, J V Joossens, H Tornqvist, B Isaksson, P Pietinen, J Tuomilehto, L Poulsen
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引用次数: 0

摘要

我们研究了11个欧洲中心尿液收集的完整性。收集的完整性是通过询问参与者,通过计算观察到的肌酐与预期肌酐的比值,并通过测量240毫克剂量后尿液中对氨基苯甲酸(PABA)的回收率来检查的。观察到的肌酐与预期的肌酐之比是一个相当不敏感的收集不足指标。那些报告说他们的收藏不完整的人很可能在很大程度上是不完整的。结论是,在流行病学研究中使用PABA仍有问题;使用PABA无法检测到过度收集,并且人们有时会忘记或拒绝服用胶囊。研究还表明,不同国家之间进餐时间模式的差异可能会干扰PABA恢复测试。
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A multi-centre study on completeness of urine collection in 11 European centres. I. Some problems with the use of creatinine and 4-aminobenzoic acid as markers of the completeness of collection.

We have studied the completeness of urine collections in 11 European centres. The completeness of collection was examined by questioning the participants, by calculating the ratio of observed to expected creatinine, and by measuring the recovery of p-aminobenzoic acid (PABA) in the urine after administration of a 240 mg dose. The ratio of observed to expected creatinine is a fairly insensitive measure of undercollection. People who report that their collection is incomplete are likely to have collected incompletely to a considerable degree. It was concluded that the use of PABA in epidemiological studies is still questionable; overcollection cannot be detected by using PABA, and it appeared that people sometimes forget or refuse to take the capsules. It is also suggested that differences in the meal-time patterns between countries may interfere with the PABA recovery test.

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