{"title":"抗独特型抗体调节格雷夫斯病的缓解吗?","authors":"R Paschke, J Teuber, U Schwedes, K H Usadel","doi":"10.1530/acta.0.114s099","DOIUrl":null,"url":null,"abstract":"<p><p>Our results show evidence for regulation of Graves' disease remission by anti-idiotypic antibodies in a biologic assay. The polyclonality and functional heterogeneity of thyroid receptor antibodies is most likely the reason why evidence for idiotypic-anti-idiotypic regulation can be demonstrated in the autologous but not consistently in the homologous system.</p>","PeriodicalId":6931,"journal":{"name":"Acta endocrinologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.114s099","citationCount":"5","resultStr":"{\"title\":\"Is remission of Graves' disease regulated by anti-idiotypic antibodies?\",\"authors\":\"R Paschke, J Teuber, U Schwedes, K H Usadel\",\"doi\":\"10.1530/acta.0.114s099\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Our results show evidence for regulation of Graves' disease remission by anti-idiotypic antibodies in a biologic assay. The polyclonality and functional heterogeneity of thyroid receptor antibodies is most likely the reason why evidence for idiotypic-anti-idiotypic regulation can be demonstrated in the autologous but not consistently in the homologous system.</p>\",\"PeriodicalId\":6931,\"journal\":{\"name\":\"Acta endocrinologica. Supplementum\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1530/acta.0.114s099\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta endocrinologica. Supplementum\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1530/acta.0.114s099\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta endocrinologica. Supplementum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1530/acta.0.114s099","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Is remission of Graves' disease regulated by anti-idiotypic antibodies?
Our results show evidence for regulation of Graves' disease remission by anti-idiotypic antibodies in a biologic assay. The polyclonality and functional heterogeneity of thyroid receptor antibodies is most likely the reason why evidence for idiotypic-anti-idiotypic regulation can be demonstrated in the autologous but not consistently in the homologous system.