用圆盘近似法和琼脂稀释法诱导实验验证头孢西丁对头孢噻肟的体外拮抗作用。

S W Chandler, F S Nolte
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引用次数: 2

摘要

耐头孢西丁肠杆菌临床分离株在47次圆盘近似试验中的31次(65.9%)和52次琼脂稀释诱导试验中的32次(63.5%)表现出可诱导的β -内酰胺酶活性。两种结果的一致性仅为72.3%,80.9%的菌株至少在一项诱导试验中呈阳性。缺乏有效的解释标准妨碍了它们在临床实验室的常规使用。
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Evaluation of disk approximation and agar dilution induction tests for demonstration of in vitro antagonism of cefotaxime by cefoxitin in Enterobacter species.

Cefoxitin-resistant clinical isolates of Enterobacter spp. demonstrated inducible beta-lactamase activity in 31 of 47 (65.9%) disk approximation tests and in 32 of 52 (63.5%) agar dilution induction tests. Agreement between the two results was only 72.3%, and 80.9% of the strains were positive in at least one induction test. Lack of valid interpretive criteria preclude their routine use in the clinical laboratory.

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