R Kikkawa, E Kitamura, Y Fujiwara, M Haneda, Y Shigeta
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引用次数: 40
摘要
研究了糖尿病大鼠肾素-血管紧张素-醛固酮系统的变化。在静脉注射链脲唑菌素(50 mg/kg体重)后1、2、4、8周，测定糖尿病大鼠和年龄匹配的对照组血浆肾素活性(PRA)、血浆血管紧张素II (A II)和醛固酮(PAC)水平。糖尿病大鼠在实验期间持续出现明显的高血糖。与对照组相比，糖尿病大鼠在第1周时PRA、Aⅱ和PAC均显著升高，在第2周时Aⅱ和PAC均显著升高。但在第4周和第8周，糖尿病大鼠的PRA、A II和PAC均明显低于对照组。糖尿病大鼠红细胞压积在第1周升高，第2、4周恢复正常，第8周下降。这些结果可能提示高血糖引起肾素-血管紧张素-醛固酮系统的双相改变，即早期由于体积消耗而处于刺激状态，后期由于体积扩张而处于抑制状态。
Biphasic alteration of renin-angiotensin-aldosterone system in streptozotocin-diabetic rats.
The alteration of renin-angiotensin-aldosterone system caused by diabetes mellitus was studied in streptozotocin-diabetic rats. The plasma renin activity (PRA), and plasma levels of angiotensin II (A II) and aldosterone (PAC) were measured in diabetic and age-matched control rats in 1, 2, 4 and 8 weeks after the intravenous injection of streptozotocin (50 mg/kg body weight). Diabetic rats showed the marked hyperglycemia persistently throughout the experimental period. On 1st week PRA, A II and PAC were significantly increased, and A II and PAC were also significantly elevated on 2nd week in diabetic rats compared with control rats. However, on 4th and 8th weeks PRA, A II and PAC in diabetic rats were significantly lower than those of control rats. Hematocrit values in diabetic rats were elevated on 1st week, normalized on 2nd and 4th weeks and then decreased on 8th week. These results may suggest that the hyperglycemia causes a biphasic alteration of renin-angiotensin-aldosterone system, i.e., early stimulated state due to volume depletion and later suppressed state due to volume expansion.
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