饮食中核苷酸对足月新生儿血浆脂肪酸的影响。

Human nutrition. Clinical nutrition Pub Date : 1986-05-01
A Gil, M Pita, A Martinez, J A Molina, F Sánchez Medina
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引用次数: 0

摘要

目前,来自母乳的非蛋白氮被认为与新生儿生理有关。人乳含有相对较多的核苷酸,而这在牛奶和配方奶中几乎是不存在的。这些化合物与动物早期的正常生长和细胞免疫有关。本研究的目的是调查饮食核苷酸对足月新生儿在生命的第一个月血浆脂肪酸模式的影响。26名婴儿被喂食母乳,35名婴儿喂食配方奶粉,23名婴儿喂食同样的配方奶粉,其中添加了与母乳中检测到的量相似的胞苷、腺苷、鸟苷、尿苷和肌苷5'-一磷酸。婴儿血浆中omega - 6家族中超过18个碳的多不饱和脂肪酸在添加了核苷酸的配方奶中显著高于添加了核苷酸的配方奶,而人乳与添加了核苷酸配方奶的婴儿血浆中omega - 6家族中超过18个碳的多不饱和脂肪酸在添加了核苷酸配方奶的婴儿血浆中没有差异。这些结果表明,饮食中的核苷酸可能参与了亚油酸在生命早期向长链多不饱和脂肪酸的转化。
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Effect of dietary nucleotides on the plasma fatty acids in at-term neonates.

Non-protein nitrogen from human milk is presently being implicated in neonatal physiology. Human milk contains relatively high amounts of nucleotides which are practically absent in cow's milk and milk formulas. These compounds have been related to normal growth and cellular immunity in animals in early life. The aim of this study was to investigate the effects of dietary nucleotides on the plasma fatty acid pattern in term neonates during the first month of life. Twenty-six infants were fed human milk, 35 a milk formula and 23 the same formula supplemented with cytidine, adenosine, guanosine, uridine and inosine 5'-monophosphates in similar quantities to those determined in human milk. Plasma polyunsaturated fatty acids with more than 18 carbons of the omega 6 family were significantly increased in infants fed with the nucleotide-supplemented milk formula with respect to those fed the milk formula, whereas no differences could be detected between the human milk-fed and the nucleotide milk formula-fed ones. These results suggest that dietary nucleotides may be involved in the conversion of linoleic acid to longer chain polyunsaturated fatty acids during early life.

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