组胺对家兔离体主动脉的影响。赛庚啶的研究[j]。

Journal de pharmacologie Pub Date : 1986-07-01
M Auguet
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引用次数: 0

摘要

在兔主动脉条上研究了组胺对血管的影响及赛庚啶对血管的抑制作用。在用苯肾上腺素预先收缩的动脉上,组胺只有在沐浴液中加入甲皮拉明时才会引起剂量依赖性松弛。这种作用与内皮细胞的完整性无关。赛庚啶(10(-9)M)需要西咪替丁的存在才能对组胺曲线产生平行拮抗作用(Kb: 0.32 nM)。在较高浓度的赛庚啶(3 × 10(-9)和10(-8)M)下,效果是非竞争性的。赛heptadine平行右移去甲肾上腺素(pA2 = 6.6)和血清素(pA2 = 8.9)的剂量反应曲线,降低了KCl (IC50 = 7.3 10(-7) M)和血管紧张素II (IC50 = 4 × 10(5) M)的收缩作用。
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[Effect of histamine on the isolated aorta of the rabbit. Study of cyproheptadine].

The vascular effects induced by histamine and their inhibition by cyproheptadine have been studied on rabbit aortic strips. On arteries pre-contracted with phenylephrine, histamine provokes a dose-dependent relaxation only when mepyramine is present in the bath. This effect is independent of the integrity of endothelium. Cyproheptadine (10(-9) M) required the presence of cimetidine to give a parallel antagonism of the histamine curve (Kb: 0.32 nM). At higher concentrations of cyproheptadine (3 X 10(-9) and 10(-8) M) the effect was non-competitive. Cyproheptadine displaced to the right in a parallel manner the dose response curve of noradrenaline (pA2 = 6.6) and of serotonin (pA2 = 8.9) and reduced the contracting effects of KCl (IC50 = 7.3 10(-7) M) and of angiotensin II (IC50 = 4 X 10(5) M).

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