[作为电离辐射生物学指标的哺乳动物精子发生]。

U Hacker-Klom, E M Meier, W Göhde
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引用次数: 0

摘要

我们用流式细胞术分析了生精细胞,以量化电离辐射的影响。本文描述了辐射诱导的NMRI近交系小鼠睾丸dna合成细胞、原代精母细胞、单倍体圆形和细长精母细胞的减少以及数量染色体畸变(异常二倍体精母细胞和非整倍体)的增加。测定睾丸重量作为生殖细胞减少的参数,并对睾丸的组织学切片进行分析。因为即使是0.05 Gy (= 5 rad)的照射也可以通过dna合成细胞的减少来检测(《放射学报》)。肿瘤防治杂志。Radiat。理论物理。生物学报,21,349-351(1982)[1]),建议使用体内系统“精子发生”作为生物剂量计来监测低剂量效应并确定不同辐射质量的RBE值。
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[Mammalian spermatogenesis as a biological indicator for ionizing radiation].

We have analysed spermatogenetic cells by flow cytometry to quantify effects of ionizing radiation. The radiation-induced reductions of testicular DNA-synthesizing cells, primary spermatocytes, haploid round and elongated spermatids as well as the increases of numerical chromosome aberrations (abnormal diploid spermatids and aneuploidies) in NMRI inbred mice are described. Testicular weights were determined as a parameter of germ cell decrease, and histologic cross sections of the testes were analysed. Since even an exposure of 0.05 Gy (= 5 rad) may be detected by a reduction of DNA-synthesizing cells (Acta Radiol. Oncol. Radiat. Phys. Biol. 21, 349-351 (1982) [1]), the use of the in vivo system "spermatogenesis" as a biological dosimeter to monitor low dose effects and to determine RBE values of different radiation qualities is suggested.

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