{"title":"用可编程袖式计算器TI 59对血液透析数据进行双池模型分析","authors":"R. Guthke , K. Günther , G. Stein , W.A. Knorre","doi":"10.1016/0010-468X(85)90010-8","DOIUrl":null,"url":null,"abstract":"<div><p>Four parameters of a two-pool model are evaluated by an iterative method using the explicit solutions of the linear differential equations. For this it was presumed that the residual renal clearance is sufficiently small. Five data pairs of measured plasma concentrations <em>c</em><sub><em>i</em></sub> for the time points <em>t</em><sub><em>i</em></sub> (<em>i</em> = 0 to 4), as well as the dialyzer and residual renal clearances (<em>K</em><sub>D</sub> and <em>K</em><sub>R</sub>), must be given and put in the calculator. A sample run is shown for urea kinetics. The parameter estimation takes about 10 min. The program is suitable to assist in the individualization of dialysis therapy.</p></div>","PeriodicalId":75731,"journal":{"name":"Computer programs in biomedicine","volume":"19 2","pages":"Pages 189-195"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0010-468X(85)90010-8","citationCount":"6","resultStr":"{\"title\":\"Two-pool model analysis of data in hemodialysis by means of programmable pocket calculator TI 59\",\"authors\":\"R. Guthke , K. Günther , G. Stein , W.A. Knorre\",\"doi\":\"10.1016/0010-468X(85)90010-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Four parameters of a two-pool model are evaluated by an iterative method using the explicit solutions of the linear differential equations. For this it was presumed that the residual renal clearance is sufficiently small. Five data pairs of measured plasma concentrations <em>c</em><sub><em>i</em></sub> for the time points <em>t</em><sub><em>i</em></sub> (<em>i</em> = 0 to 4), as well as the dialyzer and residual renal clearances (<em>K</em><sub>D</sub> and <em>K</em><sub>R</sub>), must be given and put in the calculator. A sample run is shown for urea kinetics. The parameter estimation takes about 10 min. The program is suitable to assist in the individualization of dialysis therapy.</p></div>\",\"PeriodicalId\":75731,\"journal\":{\"name\":\"Computer programs in biomedicine\",\"volume\":\"19 2\",\"pages\":\"Pages 189-195\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0010-468X(85)90010-8\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computer programs in biomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0010468X85900108\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer programs in biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0010468X85900108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
摘要
利用线性微分方程的显式解，用迭代法求出了双池模型的四个参数。因此，假定残留的肾脏清除率足够小。必须给出时间点ti (i = 0至4)的5对测量血浆浓度ci数据，以及透析器和残余肾清除率(KD和KR)，并将其输入计算器。尿素动力学的样品运行显示。参数估计大约需要10分钟。该程序适合于辅助透析治疗的个体化。
Two-pool model analysis of data in hemodialysis by means of programmable pocket calculator TI 59
Four parameters of a two-pool model are evaluated by an iterative method using the explicit solutions of the linear differential equations. For this it was presumed that the residual renal clearance is sufficiently small. Five data pairs of measured plasma concentrations ci for the time points ti (i = 0 to 4), as well as the dialyzer and residual renal clearances (KD and KR), must be given and put in the calculator. A sample run is shown for urea kinetics. The parameter estimation takes about 10 min. The program is suitable to assist in the individualization of dialysis therapy.
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