{"title":"利手、语言优势和失语症:一个遗传模型。","authors":"I C McManus","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A simple two-allele Mendelian model of the genetics of handedness is described and fitted to data in the literature. The model proposes that there are two alleles, D (dextral) and C (chance), the homozygous DD genotype producing only right-handers (directional asymmetry), the homozygous CC genotype producing a racemic mixture of 50% right-handers and 50% left-handers (fluctuating asymmetry), and the heterozygote, DC, being intermediate between the homozygotes and producing 25% left-handers, and 75% right-handers. It is also suggested that the true population incidence of left-handedness is 7.75%, deviations from this figure being due to either criterion shifts or selection biases. The same model is then fitted, by means of a number of minor conceptual extensions, to data from the literature on the relationship of handedness to language dominance, acute and permanent aphasia, and visual processing dominance.</p>","PeriodicalId":77338,"journal":{"name":"Psychological medicine. Monograph supplement","volume":"8 ","pages":"1-40"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Handedness, language dominance and aphasia: a genetic model.\",\"authors\":\"I C McManus\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A simple two-allele Mendelian model of the genetics of handedness is described and fitted to data in the literature. The model proposes that there are two alleles, D (dextral) and C (chance), the homozygous DD genotype producing only right-handers (directional asymmetry), the homozygous CC genotype producing a racemic mixture of 50% right-handers and 50% left-handers (fluctuating asymmetry), and the heterozygote, DC, being intermediate between the homozygotes and producing 25% left-handers, and 75% right-handers. It is also suggested that the true population incidence of left-handedness is 7.75%, deviations from this figure being due to either criterion shifts or selection biases. The same model is then fitted, by means of a number of minor conceptual extensions, to data from the literature on the relationship of handedness to language dominance, acute and permanent aphasia, and visual processing dominance.</p>\",\"PeriodicalId\":77338,\"journal\":{\"name\":\"Psychological medicine. Monograph supplement\",\"volume\":\"8 \",\"pages\":\"1-40\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychological medicine. Monograph supplement\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychological medicine. Monograph supplement","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Handedness, language dominance and aphasia: a genetic model.
A simple two-allele Mendelian model of the genetics of handedness is described and fitted to data in the literature. The model proposes that there are two alleles, D (dextral) and C (chance), the homozygous DD genotype producing only right-handers (directional asymmetry), the homozygous CC genotype producing a racemic mixture of 50% right-handers and 50% left-handers (fluctuating asymmetry), and the heterozygote, DC, being intermediate between the homozygotes and producing 25% left-handers, and 75% right-handers. It is also suggested that the true population incidence of left-handedness is 7.75%, deviations from this figure being due to either criterion shifts or selection biases. The same model is then fitted, by means of a number of minor conceptual extensions, to data from the literature on the relationship of handedness to language dominance, acute and permanent aphasia, and visual processing dominance.