{"title":"泛茶碱-s -磺酸钙的生化及临床研究。","authors":"R Hayakawa, K Matsunaga, C Ukei, K Ohiwa","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Calcium pantetheine-S-sulfonate (PaSSO3Ca) is one of the pantothenic acid derivatives. We examined PaSSO3Ca inhibition capacity of tyrosinase activity in vitro. For the safety evaluation when it will be applied to the human skin, we tested PaSSO3Ca creams to the fifty one patients with skin diseases by 48 hours closed patch test method. And clinical evaluation of PaSSO3Ca creams were performed in fifty patients with chloasma by half side method. Results were as follow: 1, PaSSO3Ca was proved to inhibit the tyrosinase activity in vitro. 2, PaSSO3Ca cream was shown to be safe to human skin. 3, 10% PaSSO3Ca cream lightened the skin hyperpigmentation.</p>","PeriodicalId":75427,"journal":{"name":"Acta vitaminologica et enzymologica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biochemical and clinical study of calcium pantetheine-S-sulfonate.\",\"authors\":\"R Hayakawa, K Matsunaga, C Ukei, K Ohiwa\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Calcium pantetheine-S-sulfonate (PaSSO3Ca) is one of the pantothenic acid derivatives. We examined PaSSO3Ca inhibition capacity of tyrosinase activity in vitro. For the safety evaluation when it will be applied to the human skin, we tested PaSSO3Ca creams to the fifty one patients with skin diseases by 48 hours closed patch test method. And clinical evaluation of PaSSO3Ca creams were performed in fifty patients with chloasma by half side method. Results were as follow: 1, PaSSO3Ca was proved to inhibit the tyrosinase activity in vitro. 2, PaSSO3Ca cream was shown to be safe to human skin. 3, 10% PaSSO3Ca cream lightened the skin hyperpigmentation.</p>\",\"PeriodicalId\":75427,\"journal\":{\"name\":\"Acta vitaminologica et enzymologica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta vitaminologica et enzymologica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta vitaminologica et enzymologica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
pantetheine- s -磺酸钙(PaSSO3Ca)是泛酸衍生物之一。我们在体外检测了PaSSO3Ca对酪氨酸酶活性的抑制能力。为了评价PaSSO3Ca面霜在人体皮肤上应用的安全性，我们对51例皮肤病患者采用48小时封闭斑贴试验法进行了PaSSO3Ca面霜的临床试验。采用半侧法对50例黄褐斑患者进行PaSSO3Ca乳膏的临床评价。结果表明:1、PaSSO3Ca对酪氨酸酶活性有抑制作用。PaSSO3Ca乳霜被证明对人体皮肤是安全的。3、10% PaSSO3Ca乳霜淡化皮肤色素沉着。
Biochemical and clinical study of calcium pantetheine-S-sulfonate.
Calcium pantetheine-S-sulfonate (PaSSO3Ca) is one of the pantothenic acid derivatives. We examined PaSSO3Ca inhibition capacity of tyrosinase activity in vitro. For the safety evaluation when it will be applied to the human skin, we tested PaSSO3Ca creams to the fifty one patients with skin diseases by 48 hours closed patch test method. And clinical evaluation of PaSSO3Ca creams were performed in fifty patients with chloasma by half side method. Results were as follow: 1, PaSSO3Ca was proved to inhibit the tyrosinase activity in vitro. 2, PaSSO3Ca cream was shown to be safe to human skin. 3, 10% PaSSO3Ca cream lightened the skin hyperpigmentation.
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