AMP对犬缺血心肌加速恢复的初步报道。

Advances in myocardiology Pub Date : 1985-01-01

H M Sami, J R Koke, N Bittar

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引用次数: 0

摘要

采用原位血流灌注犬心脏模型对18只犬进行了实验。冠状动脉内灌注AMP导致ATP和总腺嘌呤核苷酸水平升高。缺血15分钟后再灌注时，ATP和总腺嘌呤核苷酸水平显著高于对照组。最重要的是，接受amp治疗的狗的收缩功能恢复得更快。因此，我们得出结论，缺血后功能恢复的延迟可能是ATP再合成延迟的直接结果。

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Accelerated recovery of ischemic canine myocardium induced by AMP. Preliminary report.

Experiments were conducted on 18 dogs using an in situ blood-perfused canine heart model. Intracoronary infusion of AMP resulted in increased ATP and total adenine nucleotide levels. On reperfusion following a 15-min period of ischemia, ATP and total adenine nucleotide levels were significantly higher than control. Most important, contractile function recovered more rapidly in the AMP-treated dogs. It is therefore concluded that the delayed functional recovery noted after periods of ischemia is likely to be a direct result of delayed ATP resynthesis.

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Advances in myocardiology

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