乳腺癌患者的色氨酸代谢。

Acta vitaminologica et enzymologica Pub Date : 1985-01-01

J M Poulter, J W Dickerson, W F White

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引用次数: 0

摘要

51例乳腺癌患者的血浆总色氨酸水平明显低于14例良性乳腺癌患者在手术后12周的血浆总色氨酸水平。肿瘤患者和良性疾病患者尿中黄嘌呤酸和5-羟基吲哚乙酸的排泄量相似，但肿瘤患者尿中N′-甲基烟酰胺(NMN)的排泄量显著高于肿瘤患者(P < 0.001)。这表明尿中NMN排泄量的升高是由于NAD活性的升高反映了通过Cori循环糖酵解的升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tryptophan metabolism in patients with breast cancer.

Plasma levels of total tryptophan were significantly lower in 51 patients with breast cancer than in 14 women with benign breast cancer following surgery and after 12 weeks. The urinary excretion of xanthurenic and 5-hydroxyindoleacetic acids were similar in patients with cancer and benign disease but the excretion of N'-methylnicotinamide (NMN) was significantly higher (P less than 0.001) in the cancer patients. It is suggested that the elevated urinary excretions of NMN is due to higher NAD activity reflecting elevated glycolysis through the Cori cycle.

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Acta vitaminologica et enzymologica

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