G.W. Kabalka , R.M. Lambrecht , M. Sajjad , J.S. Fowler , S.A. Kunda , G.W. McCollum , R. MacGregor
{"title":"有机硼烷化学法合成15o标记丁醇","authors":"G.W. Kabalka , R.M. Lambrecht , M. Sajjad , J.S. Fowler , S.A. Kunda , G.W. McCollum , R. MacGregor","doi":"10.1016/0020-708X(85)90017-1","DOIUrl":null,"url":null,"abstract":"<div><p>Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O<sub>2</sub>−<sup>15</sup>O with tri-<em>n</em>-butylborane and tri-<em>sec</em>-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of <sup>15</sup>O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.</p></div>","PeriodicalId":22517,"journal":{"name":"The International journal of applied radiation and isotopes","volume":"36 11","pages":"Pages 853-855"},"PeriodicalIF":0.0000,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-708X(85)90017-1","citationCount":"46","resultStr":"{\"title\":\"Synthesis of 15O-labeled butanol via organoborane chemistry\",\"authors\":\"G.W. Kabalka , R.M. Lambrecht , M. Sajjad , J.S. Fowler , S.A. Kunda , G.W. McCollum , R. MacGregor\",\"doi\":\"10.1016/0020-708X(85)90017-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O<sub>2</sub>−<sup>15</sup>O with tri-<em>n</em>-butylborane and tri-<em>sec</em>-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of <sup>15</sup>O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.</p></div>\",\"PeriodicalId\":22517,\"journal\":{\"name\":\"The International journal of applied radiation and isotopes\",\"volume\":\"36 11\",\"pages\":\"Pages 853-855\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0020-708X(85)90017-1\",\"citationCount\":\"46\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The International journal of applied radiation and isotopes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0020708X85900171\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International journal of applied radiation and isotopes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0020708X85900171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis of 15O-labeled butanol via organoborane chemistry
Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O2−15O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
