软组织肉瘤的中子治疗效果。

Strahlentherapie Pub Date : 1985-12-01
H J Eichhorn, K H Dallüge
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引用次数: 0

摘要

用快中子照射82例主要位于躯干和四肢的耐辐射间充质肉瘤。在应用的所有三个肿瘤剂量范围(6 - 9.6 Gy, 10 - 12.6 Gy和13 - 19 Gy)中,90%的肿瘤观察到完全(与50%一致)或部分(与40%一致)的回归;只有10%的人没有反应。另外53例软组织肉瘤,局部切除后自发复发率高达50%,术后接受肿瘤剂量约10 Gy的预防性照射。在45例调查至少2年的病例中,有7例(15%)在辐照区复发。中子辐射治疗软组织肉瘤的复发率高,预防复发效果好,剂量耐受良好,特别适合于软组织肉瘤的治疗。
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Results of neutron therapy of soft-tissue sarcomas.

82 radioresistant mesenchymal sarcomas localized mainly at the trunk and the extremities have been irradiated with fast neutrons. In all three tumor dose ranges applied (6 to 9.6, 10 to 12.6, and 13 to 19 Gy) alike with 90% of the tumors either complete (congruent to 50%) or partial (congruent to 40%) regressions were observed; only 10% were unresponsive. Further 53 soft tissue sarcomas, showing a spontaneous recurrence rate following local extirpation up to 50%, underwent postoperative prophylactic irradiation with tumor doses of about 10 Gy. In 45 cases surveyed for at least two years, there developed seven (15%) recurrences in the irradiation field. The high regression rate and the good prophylactic effect against recurrences with doses well tolerable, render neutron radiation especially suitable for the treatment of soft tissue sarcomas.

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Proton therapy at Harvard. Proton radiotherapy with the Uppsala cyclotron. Experience and plans. Neutron radiobiology and clinical consequences. Review and evolution of clinical results in the EORTC Heavy-Particle Therapy Group. Results of curative pion therapy at SIN.
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