{"title":"大鼠脑内立体定向注射氧tremorine和tremorine致震颤作用的研究","authors":"B. Cox, D. Potkonjak","doi":"10.1016/0028-3908(69)90050-1","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of stereotaxic administration of tremorine and oxotremorine into four brain areas has been investigated using rats. Tremorine produced tremor significantly higher than control after administration into the globus pallidus, caudate nucleus, and substantia nigra. Oxotremorine produced tremor significantly higher than control only after injection into the substantia nigra. Dyflos injected into the caudate nucleus produced tremor. No change in the tremorgenic action of tremorine was observed after the simultaneous intracaudate injections of atropine and tremorine, and dyflos and tremorine. Intraperitoneal atropine reduced the tremorgenic action of an intracaudate injection of tremorine.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 3","pages":"Pages 291-297, IN15"},"PeriodicalIF":0.0000,"publicationDate":"1969-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90050-1","citationCount":"20","resultStr":"{\"title\":\"An investigation of the tremorgenic effects of oxotremorine and tremorine after stereotaxic injection into rat brain\",\"authors\":\"B. Cox, D. Potkonjak\",\"doi\":\"10.1016/0028-3908(69)90050-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effect of stereotaxic administration of tremorine and oxotremorine into four brain areas has been investigated using rats. Tremorine produced tremor significantly higher than control after administration into the globus pallidus, caudate nucleus, and substantia nigra. Oxotremorine produced tremor significantly higher than control only after injection into the substantia nigra. Dyflos injected into the caudate nucleus produced tremor. No change in the tremorgenic action of tremorine was observed after the simultaneous intracaudate injections of atropine and tremorine, and dyflos and tremorine. Intraperitoneal atropine reduced the tremorgenic action of an intracaudate injection of tremorine.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":\"8 3\",\"pages\":\"Pages 291-297, IN15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(69)90050-1\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390869900501\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900501","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
An investigation of the tremorgenic effects of oxotremorine and tremorine after stereotaxic injection into rat brain
The effect of stereotaxic administration of tremorine and oxotremorine into four brain areas has been investigated using rats. Tremorine produced tremor significantly higher than control after administration into the globus pallidus, caudate nucleus, and substantia nigra. Oxotremorine produced tremor significantly higher than control only after injection into the substantia nigra. Dyflos injected into the caudate nucleus produced tremor. No change in the tremorgenic action of tremorine was observed after the simultaneous intracaudate injections of atropine and tremorine, and dyflos and tremorine. Intraperitoneal atropine reduced the tremorgenic action of an intracaudate injection of tremorine.
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