{"title":"葡聚糖-40的降胆固醇作用","authors":"J. Ditzel, J. Dyerberg","doi":"10.1016/S0368-1319(69)80076-1","DOIUrl":null,"url":null,"abstract":"<div><p>During a double-blind investigation of the haemorrheological effects of low molecular weight dextran (mol.wt. 40,000) in 33 patients with acute myocardial infarction, a significant cholesterol-lowering effect of Dextran-40 was demonstrated.</p><p>The average serum cholesterol level decreased from 264 mg/100 ml to 166 mg/100 ml on the 7th day in the group of patients receiving a daily infusion of 500 ml of Dextran-40 for 5 days, whereas the serum cholesterol level only decreased from 289 mg/100 ml-240 mg/100 ml in the placebo group. The possible mechanism of the hypolipidaemic effect of dextran and other osmotic active compounds is discussed.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 5-10"},"PeriodicalIF":0.0000,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80076-1","citationCount":"6","resultStr":"{\"title\":\"The cholesterol-lowering effect of dextran-40\",\"authors\":\"J. Ditzel, J. Dyerberg\",\"doi\":\"10.1016/S0368-1319(69)80076-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>During a double-blind investigation of the haemorrheological effects of low molecular weight dextran (mol.wt. 40,000) in 33 patients with acute myocardial infarction, a significant cholesterol-lowering effect of Dextran-40 was demonstrated.</p><p>The average serum cholesterol level decreased from 264 mg/100 ml to 166 mg/100 ml on the 7th day in the group of patients receiving a daily infusion of 500 ml of Dextran-40 for 5 days, whereas the serum cholesterol level only decreased from 289 mg/100 ml-240 mg/100 ml in the placebo group. The possible mechanism of the hypolipidaemic effect of dextran and other osmotic active compounds is discussed.</p></div>\",\"PeriodicalId\":78351,\"journal\":{\"name\":\"Journal of atherosclerosis research\",\"volume\":\"10 1\",\"pages\":\"Pages 5-10\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80076-1\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of atherosclerosis research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0368131969800761\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of atherosclerosis research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0368131969800761","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
During a double-blind investigation of the haemorrheological effects of low molecular weight dextran (mol.wt. 40,000) in 33 patients with acute myocardial infarction, a significant cholesterol-lowering effect of Dextran-40 was demonstrated.
The average serum cholesterol level decreased from 264 mg/100 ml to 166 mg/100 ml on the 7th day in the group of patients receiving a daily infusion of 500 ml of Dextran-40 for 5 days, whereas the serum cholesterol level only decreased from 289 mg/100 ml-240 mg/100 ml in the placebo group. The possible mechanism of the hypolipidaemic effect of dextran and other osmotic active compounds is discussed.
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