{"title":"对氯苯丙氨酸对小鼠和大鼠行为和生化影响的相关性研究","authors":"L. Volicer","doi":"10.1016/0028-3908(69)90022-7","DOIUrl":null,"url":null,"abstract":"<div><p>The relationship between brain monoanunes and the behavioral effect of<em>p-chlorophenylalanine</em> in mice and rats was investigated. When brain serotonin was depleted by<em>p-chlorophenylalanine</em> spontaneous motor activity was decreased only in rats. Administration of<em>p-chlorophenylalanine</em> changed neither the brain levels of catecholamines in both species nor the turnover rate of brain norepinephrine and dopamine in rats. These results suggest that the decrease of spontaneous motor activity after<em>p</em> chlorophenylalanine administration is probably not mediated through serotonin or the catecholamines and that another mode of<em>p-chlorophenylalanine</em> action must be supposed.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 4","pages":"Pages 361-364"},"PeriodicalIF":0.0000,"publicationDate":"1969-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90022-7","citationCount":"54","resultStr":"{\"title\":\"Correlation between behavioral and biochemical effects of p-chlorophenylalanine in mice and rats\",\"authors\":\"L. Volicer\",\"doi\":\"10.1016/0028-3908(69)90022-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The relationship between brain monoanunes and the behavioral effect of<em>p-chlorophenylalanine</em> in mice and rats was investigated. When brain serotonin was depleted by<em>p-chlorophenylalanine</em> spontaneous motor activity was decreased only in rats. Administration of<em>p-chlorophenylalanine</em> changed neither the brain levels of catecholamines in both species nor the turnover rate of brain norepinephrine and dopamine in rats. These results suggest that the decrease of spontaneous motor activity after<em>p</em> chlorophenylalanine administration is probably not mediated through serotonin or the catecholamines and that another mode of<em>p-chlorophenylalanine</em> action must be supposed.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":\"8 4\",\"pages\":\"Pages 361-364\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(69)90022-7\",\"citationCount\":\"54\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390869900227\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900227","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Correlation between behavioral and biochemical effects of p-chlorophenylalanine in mice and rats
The relationship between brain monoanunes and the behavioral effect ofp-chlorophenylalanine in mice and rats was investigated. When brain serotonin was depleted byp-chlorophenylalanine spontaneous motor activity was decreased only in rats. Administration ofp-chlorophenylalanine changed neither the brain levels of catecholamines in both species nor the turnover rate of brain norepinephrine and dopamine in rats. These results suggest that the decrease of spontaneous motor activity afterp chlorophenylalanine administration is probably not mediated through serotonin or the catecholamines and that another mode ofp-chlorophenylalanine action must be supposed.
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