{"title":"秋水仙碱对人血小板行为的影响","authors":"G.D. Soppitt, J.R.A. Mitchell","doi":"10.1016/S0368-1319(69)80012-8","DOIUrl":null,"url":null,"abstract":"<div><p>Colchicine is known to inhibit clot retraction. We have found that it also inhibits platelet aggregation produced by ADP, by nor-adrenaline and by “collagen”, and that it reduces platelet adhesiveness. The inhibition of aggregation by colchicine does not seem to be mediated by —SH blockade, nor does it depend on the availability of an acetyl side-chain.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 2","pages":"Pages 247-252"},"PeriodicalIF":0.0000,"publicationDate":"1969-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80012-8","citationCount":"19","resultStr":"{\"title\":\"The effect of colchicine on human platelet behaviour\",\"authors\":\"G.D. Soppitt, J.R.A. Mitchell\",\"doi\":\"10.1016/S0368-1319(69)80012-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Colchicine is known to inhibit clot retraction. We have found that it also inhibits platelet aggregation produced by ADP, by nor-adrenaline and by “collagen”, and that it reduces platelet adhesiveness. The inhibition of aggregation by colchicine does not seem to be mediated by —SH blockade, nor does it depend on the availability of an acetyl side-chain.</p></div>\",\"PeriodicalId\":78351,\"journal\":{\"name\":\"Journal of atherosclerosis research\",\"volume\":\"10 2\",\"pages\":\"Pages 247-252\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80012-8\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of atherosclerosis research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0368131969800128\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of atherosclerosis research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0368131969800128","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of colchicine on human platelet behaviour
Colchicine is known to inhibit clot retraction. We have found that it also inhibits platelet aggregation produced by ADP, by nor-adrenaline and by “collagen”, and that it reduces platelet adhesiveness. The inhibition of aggregation by colchicine does not seem to be mediated by —SH blockade, nor does it depend on the availability of an acetyl side-chain.
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