{"title":"吲哚酚衍生物:潜在的精神药物代谢物","authors":"Robert G. Taborsky","doi":"10.1016/0028-3908(68)90058-0","DOIUrl":null,"url":null,"abstract":"<div><p>Effects of indole, indican, 1-methylindole, 1-methylindican, indoxylo-acetate, adrenochrome, adrenolutin, adrenochrome methyl ether, and 5,66-dihydroxy-1-methylindole were examined on activity of rats doing a variable-interval, positive-reinforcement task (bar pressing for food reward). All of the 3-hydroxylated indoles with the exception of indican were active. When the 3-hydroxyl group was blocked or removed, as in adrenochrome methyl ether or 5, 6-dihydroxyl1-methylindole, activity was lost completely. 1-Methylindole was also active, but a study of its metabolism showed it to be converted to 1-methylindican, which is probably the active agent. A side observation was that ethanol exhibited a synergistic effect to indoxylo-acetate.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(68)90058-0","citationCount":"12","resultStr":"{\"title\":\"Indoxyl derivatives: Potential psychotropic metabolites\",\"authors\":\"Robert G. Taborsky\",\"doi\":\"10.1016/0028-3908(68)90058-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Effects of indole, indican, 1-methylindole, 1-methylindican, indoxylo-acetate, adrenochrome, adrenolutin, adrenochrome methyl ether, and 5,66-dihydroxy-1-methylindole were examined on activity of rats doing a variable-interval, positive-reinforcement task (bar pressing for food reward). All of the 3-hydroxylated indoles with the exception of indican were active. When the 3-hydroxyl group was blocked or removed, as in adrenochrome methyl ether or 5, 6-dihydroxyl1-methylindole, activity was lost completely. 1-Methylindole was also active, but a study of its metabolism showed it to be converted to 1-methylindican, which is probably the active agent. A side observation was that ethanol exhibited a synergistic effect to indoxylo-acetate.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1968-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(68)90058-0\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390868900580\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390868900580","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of indole, indican, 1-methylindole, 1-methylindican, indoxylo-acetate, adrenochrome, adrenolutin, adrenochrome methyl ether, and 5,66-dihydroxy-1-methylindole were examined on activity of rats doing a variable-interval, positive-reinforcement task (bar pressing for food reward). All of the 3-hydroxylated indoles with the exception of indican were active. When the 3-hydroxyl group was blocked or removed, as in adrenochrome methyl ether or 5, 6-dihydroxyl1-methylindole, activity was lost completely. 1-Methylindole was also active, but a study of its metabolism showed it to be converted to 1-methylindican, which is probably the active agent. A side observation was that ethanol exhibited a synergistic effect to indoxylo-acetate.