乙肝病毒DNA在人肝癌组织中表达的直接证据。

Gan Pub Date : 1984-09-01

K Yaginuma, H Kobayashi, E Yoshida, M Kobayashi, K Koike

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引用次数: 0

摘要

研究了一名11岁男孩肝癌组织#1707中乙型肝炎病毒DNA的细胞内结构和表达。结果发现，大部分HBV基因组存在于#1707 DNA中。印迹杂交也证实了病毒特异性的21S mRNA。这是人类肝癌组织中整合病毒基因组表达的第一个直接证据。

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Direct evidence for the expression of integrated hepatitis B virus DNA in human hepatoma tissue.

The intracellular structure and expression of integrated hepatitis B virus (HBV) DNA in the hepatoma tissue #1707 obtained from an 11-year-old boy were studied. It was found that most of the HBV genome was present in the #1707 DNA. Virus-specific 21S mRNA was also demonstrated by blot hybridization. This is the first direct evidence for the expression of the integrated viral genome in human hepatoma tissue.

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Gan

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