儿童白血病缓解期减毒水痘活疫苗的研究

Biken journal Pub Date : 1984-09-01
A A Gershon, S Steinberg, G Galasso, W Borkowsky, P Larussa, A Ferrara, L Gelb
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引用次数: 0

摘要

191名急性白血病缓解至少一年的儿童接种了1剂或更多剂量的减毒水痘活疫苗。所有人在接种疫苗前都易患水痘。唯一显著的副作用是轻度至中度皮疹,特别是在疫苗接种前和接种后一周暂停维持化疗的儿童中。有皮疹的儿童有一定风险(10%)将疫苗病毒传播给与其密切接触的水痘易感人群。
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Live attenuated varicella vaccine in children with leukemia in remission.

One-hundred-ninety-one children with acute leukemia in remission for at least one year were immunized with 1 or more doses of live attenuated varicella vaccine. All were susceptible to varicella prior to vaccination. The only significant side effect was mild to moderate rash, seen especially in children with maintenance chemotherapy temporarily suspended for one week before and one week after vaccination. Children with rash were at some risk (10%) to transmit vaccine virus to varicella susceptibles with whom they had close contact.

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