S Yoshida, T Tamura, M Tamura, M Takeshita, H Terao, T Fujioka, T Itoga
{"title":"高胆固醇血症患者肝癌组织中脂肪酸甲酯存在的证据。","authors":"S Yoshida, T Tamura, M Tamura, M Takeshita, H Terao, T Fujioka, T Itoga","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The lipid composition of a human hepatoma tissue (liver cell carcinoma) was examined by thin-layer chromatography (TLC), and an unusual lipid spot was found in a large quantity. It was identified as consisting of fatty acid methyl esters by TLC and gas chromatography-mass spectrometry techniques. In the fatty acid methyl ester fraction, oleate (18:1) and palmitate (16:0) were dominant. Furthermore, very unusual fatty acid methyl esters, such as methyl 2-methyl oleate, were detected. These unusual lipids could be detected neither in cirrhotic lesions of the host liver nor in normal control tissues.</p>","PeriodicalId":14978,"journal":{"name":"Journal of applied biochemistry","volume":"6 5-6","pages":"314-8"},"PeriodicalIF":0.0000,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evidence for the presence of fatty acid methyl esters in human hepatoma tissue from a patient with hypercholesterolemia.\",\"authors\":\"S Yoshida, T Tamura, M Tamura, M Takeshita, H Terao, T Fujioka, T Itoga\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The lipid composition of a human hepatoma tissue (liver cell carcinoma) was examined by thin-layer chromatography (TLC), and an unusual lipid spot was found in a large quantity. It was identified as consisting of fatty acid methyl esters by TLC and gas chromatography-mass spectrometry techniques. In the fatty acid methyl ester fraction, oleate (18:1) and palmitate (16:0) were dominant. Furthermore, very unusual fatty acid methyl esters, such as methyl 2-methyl oleate, were detected. These unusual lipids could be detected neither in cirrhotic lesions of the host liver nor in normal control tissues.</p>\",\"PeriodicalId\":14978,\"journal\":{\"name\":\"Journal of applied biochemistry\",\"volume\":\"6 5-6\",\"pages\":\"314-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of applied biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied biochemistry","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evidence for the presence of fatty acid methyl esters in human hepatoma tissue from a patient with hypercholesterolemia.
The lipid composition of a human hepatoma tissue (liver cell carcinoma) was examined by thin-layer chromatography (TLC), and an unusual lipid spot was found in a large quantity. It was identified as consisting of fatty acid methyl esters by TLC and gas chromatography-mass spectrometry techniques. In the fatty acid methyl ester fraction, oleate (18:1) and palmitate (16:0) were dominant. Furthermore, very unusual fatty acid methyl esters, such as methyl 2-methyl oleate, were detected. These unusual lipids could be detected neither in cirrhotic lesions of the host liver nor in normal control tissues.
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