胆碱能药物引起的惊厥活动的脑电图分析

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90089-8

Steven L. Cohen , Barbara J. Morley , O.Carter Snead

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引用次数: 31

摘要

1.1. 在大鼠脑室内注射胆碱能激动剂(氨甲酰胆碱和酒石酸尼古丁)、尼古丁拮抗剂(d-管柯碱和α-班加罗毒素)、神经节阻滞剂(甲胺胺和六甲基铵)、十甲基铵、纯化电鱼乙酰胆碱受体制备的抗体以及肌无力和癫痫患者的人血清后，评估其脑电图活动。癫痫发作仅由激动剂和尼古丁拮抗剂引起。氨甲酰胆碱引起阵挛/强直性惊厥。尼古丁导致脑电图下降并伴有偶发癫痫发作。两种拮抗剂均产生阵挛/强直性癫痫发作和尖峰活动。东莨菪碱可阻断氨甲酰胆碱诱导的癫痫发作。没有发现任何药物可以阻断拮抗剂诱导的癫痫发作。

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An EEG analysis of convulsive activity produced by cholinergic agents

1.
1. EEG activity was assessed in rats following the intraventricular injection of cholinergic agonists (carbamylcholine and nicotine tartrate), nicotinic antagonists (d-tubocurarine and α-bungarotoxin), ganglionic blockers (mecamylamine and hexamethonium), decamethonium, antibodies prepared against purified electric fish acetylcholine receptor, and human sera from myasthenic and epileptic patients.
2.
2. Seizures were produced only by agonists and nicotinic antagonists.
3.
3. Carbamylcholine produced clonic/tonic convulsions. Nicotine resulted in a depressed EEG with sporadic seizures.
4.
4. Both antagonists produced clonic/tonic seizures and spike activity. Carbamylcholine-induced seizures were blocked by scopolamine.
5.
5. No agent was found to block antagonist-induced seizures.

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