大肠杆菌黏附因子“119”在哺乳小鼠尿路模型中致病作用的免疫学研究。

I Kétyi
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引用次数: 0

摘要

在尿路感染过程中,具有母体抗毛杆菌(“119”)免疫的哺乳小鼠对119+大肠杆菌菌株表现出巨大的保护作用。在感染后不久,通过注射毛疱抗体或毛疱疫苗,可以保护动物免受尿路感染。结果显示粘连菌毛在引起大肠杆菌尿路感染中的重要作用。
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Immunological approach to the pathogenetical role of Escherichia coli adhesive factor "119" in a suckling mouse urinary tract model.

In the course of urinary tract infections, suckling mice with maternal anti-pilus ("119") immunity showed a massive protection against a 119+ strain of Escherichia coli. Animals could be protected against urinary tract infection by giving pilus antibody or pilus vaccine shortly after the infection. Results showed the importance of adhesive pili in initiating the urinary tract infection by E. coli.

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Immunological approach to the pathogenetical role of Escherichia coli adhesive factor "119" in a suckling mouse urinary tract model. Pilus antigen 987P produced by strains of Escherichia coli serotypes O141:K--, H- and O8:K85:H--. Protective role of O antigen in Salmonella typhi-murium infection. Higher resistance of germfree mice to dianhydrodulcitol, a lymphotropic cytostatic agent. [Use of the rabbit testicular cells in the plaque assay for herpesvirus hominis type 1 and 2].
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