{"title":"培养基成分改变甲胎蛋白(AFP)对淋巴细胞反应的影响","authors":"M. Czokalo, L. Wiśniewski","doi":"10.1016/S0014-4908(80)80035-4","DOIUrl":null,"url":null,"abstract":"<div><p>Incorporation of [methyl-<sup>3</sup>H]thymidine to DNA of lymphocytes cultured in the presence of various concentrations of alpha-fetoprotein (AFP) from human cord blood serum was investigated. It was found that AFP by itself does not exert mitogenic effects. In phytohemagglutinin (PHA) stimulated cultures it may inhibit DNA biosynthesis or exert augmentative effect on this process dependent on the composition of the culture medium.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 5","pages":"Pages 297-301"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80035-4","citationCount":"1","resultStr":"{\"title\":\"Culture medium components modify the effects exerted by alpha-fetoprotein (AFP) on lymphocyte response\",\"authors\":\"M. Czokalo, L. Wiśniewski\",\"doi\":\"10.1016/S0014-4908(80)80035-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Incorporation of [methyl-<sup>3</sup>H]thymidine to DNA of lymphocytes cultured in the presence of various concentrations of alpha-fetoprotein (AFP) from human cord blood serum was investigated. It was found that AFP by itself does not exert mitogenic effects. In phytohemagglutinin (PHA) stimulated cultures it may inhibit DNA biosynthesis or exert augmentative effect on this process dependent on the composition of the culture medium.</p></div>\",\"PeriodicalId\":75841,\"journal\":{\"name\":\"Experimentelle Pathologie\",\"volume\":\"18 5\",\"pages\":\"Pages 297-301\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80035-4\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimentelle Pathologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014490880800354\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimentelle Pathologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014490880800354","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Culture medium components modify the effects exerted by alpha-fetoprotein (AFP) on lymphocyte response
Incorporation of [methyl-3H]thymidine to DNA of lymphocytes cultured in the presence of various concentrations of alpha-fetoprotein (AFP) from human cord blood serum was investigated. It was found that AFP by itself does not exert mitogenic effects. In phytohemagglutinin (PHA) stimulated cultures it may inhibit DNA biosynthesis or exert augmentative effect on this process dependent on the composition of the culture medium.
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