{"title":"[改变肝细胞嘌呤代谢的因素]。","authors":"M Lalanne, C Des Rosiers, J Willemot","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This paper reviews results of a study of various factors altering 5-phosphoribosyl-1-pyrophosphate (PRPP) availability in freshly isolated rat liver cells. Total PRPP availability is not changed in the presence of allopurinol but in the competition for available PRPP is increased. Changes of PRPP availability due to phosphate, electron acceptors, or glycerol are usually accompanied by similar changes in the rate of purines synthesis de novo.</p>","PeriodicalId":79252,"journal":{"name":"Revue canadienne de biologie experimentale","volume":"41 1","pages":"65-71"},"PeriodicalIF":0.0000,"publicationDate":"1982-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Factors altering purine metabolism in liver cells].\",\"authors\":\"M Lalanne, C Des Rosiers, J Willemot\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This paper reviews results of a study of various factors altering 5-phosphoribosyl-1-pyrophosphate (PRPP) availability in freshly isolated rat liver cells. Total PRPP availability is not changed in the presence of allopurinol but in the competition for available PRPP is increased. Changes of PRPP availability due to phosphate, electron acceptors, or glycerol are usually accompanied by similar changes in the rate of purines synthesis de novo.</p>\",\"PeriodicalId\":79252,\"journal\":{\"name\":\"Revue canadienne de biologie experimentale\",\"volume\":\"41 1\",\"pages\":\"65-71\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revue canadienne de biologie experimentale\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue canadienne de biologie experimentale","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Factors altering purine metabolism in liver cells].
This paper reviews results of a study of various factors altering 5-phosphoribosyl-1-pyrophosphate (PRPP) availability in freshly isolated rat liver cells. Total PRPP availability is not changed in the presence of allopurinol but in the competition for available PRPP is increased. Changes of PRPP availability due to phosphate, electron acceptors, or glycerol are usually accompanied by similar changes in the rate of purines synthesis de novo.
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