棉酚对肾脏atp酶活性的影响。

Scientia Sinica Pub Date : 1981-04-01

X F Bi, Y J Zheng, H F Yang, Z R Zhang

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引用次数: 0

摘要

本研究结果显示，给药半年后，大鼠肾皮质atp酶活性没有变化。棉酚喂养5周和9周后，豚鼠肾皮质细胞膜的Na+、K+- atp酶活性明显改变。似乎有可能通过让豚鼠随意食用富含钾的食物来减少或延缓这种抑制作用。在体外实验中，棉酚对大鼠和豚鼠大脑和肾脏的atp酶活性有明显的非竞争性抑制作用。然而，人胎儿肾脏对atp酶的抑制呈混合型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The effect of gossypol on ATPase activity of the kidney.

The results of the present study have shown no change in the activity of ATPase of the renal cortex of rats administered gossypol for half a year. The Na+, K+-ATPase activity of the cellular membrane of renal cortex of guinea pigs fed with gossypol for 5 or 9 weeks is significantly altered. It seems possible to diminish or to delay the inhibition by allowing the guinea pigs a potassium-rich diet ad libitum. In vitro, gossypol inhibits significantly the activity of ATPase of the brain and the kidney of rats and guinea pigs uncompetitively. However, the inhibition of the ATPase of human fetus kidney is of a mixed type.

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Scientia Sinica

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