[不饱和脂肪酸对未成熟雌性大鼠子宫雌激素结合的抑制作用]。

F Clerc-Hofmann, G Vallette, C Secco-Millet, N Christeff, C Benassayag, E A Nunez
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引用次数: 0

摘要

我们证明24日龄大鼠子宫细胞质蛋白与雌二醇-17 β (E2)之间的相互作用受到非酯化脂肪酸生理浓度的显著影响(2)。10 (4) M)。我们发现该激素与8S子宫受体的特异性结合被不饱和脂肪酸显著抑制(50-80%)。所观察到的抑制作用是酸剂量和酸不饱和度的函数。多不饱和花生四烯酸和二十二碳六烯酸是最强的抑制剂,而饱和棕榈酸和硬脂酸不会取代8S受体中的E2。
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[Inhibition of the uterine binding of estrogens by unsaturated fatty acids in immature female rats].

We demonstrate that the interactions between the uterine cytosol proteins of 24 day old Rats and estradiol-17 beta (E2) are significantly influenced by physiological concentrations of non esterified fatty acids (2. 10(-4)M). We show that the specific binding of the hormone to the 8S uterine receptor, is markedly inhibited (50-80%) by the unsaturated fatty acids. The observed inhibition is a function both of acid dose and acid unsaturation degree. The polyunsaturated arachidonic and docosahexaenoic acids are the strongest inhibitors, whereas the saturated palmitic and stearic acids do not displace the E2 from the 8S receptor.

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