在过氧化氢和铁离子存在下，多酚和氨基酚在C-8位羟基化脱氧鸟苷。

Gan Pub Date : 1984-07-01

H Kasai, S Nishimura

{"title":"在过氧化氢和铁离子存在下，多酚和氨基酚在C-8位羟基化脱氧鸟苷。","authors":"H Kasai, S Nishimura","doi":"","DOIUrl":null,"url":null,"abstract":"Various polyphenols and aminophenols were tested for reactivity with deoxyguanosine and DNA in the presence of hydrogen peroxide and ferric ion. Deoxyguanosine was efficiently hydroxylated at the C-8 position by these treatments. In the case of DNA, strand scission was observed in addition to the hydroxylation of guanine residues.","PeriodicalId":12660,"journal":{"name":"Gan","volume":"75 7","pages":"565-6"},"PeriodicalIF":0.0000,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion.\",\"authors\":\"H Kasai, S Nishimura\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Various polyphenols and aminophenols were tested for reactivity with deoxyguanosine and DNA in the presence of hydrogen peroxide and ferric ion. Deoxyguanosine was efficiently hydroxylated at the C-8 position by these treatments. In the case of DNA, strand scission was observed in addition to the hydroxylation of guanine residues.\",\"PeriodicalId\":12660,\"journal\":{\"name\":\"Gan\",\"volume\":\"75 7\",\"pages\":\"565-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gan","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

在过氧化氢和铁离子存在下，测试了各种多酚和氨基酚与脱氧鸟苷和DNA的反应性。这些处理能有效地使脱氧鸟苷在C-8位羟基化。在DNA的情况下，除了鸟嘌呤残基的羟基化外，还观察到链断裂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion.

Various polyphenols and aminophenols were tested for reactivity with deoxyguanosine and DNA in the presence of hydrogen peroxide and ferric ion. Deoxyguanosine was efficiently hydroxylated at the C-8 position by these treatments. In the case of DNA, strand scission was observed in addition to the hydroxylation of guanine residues.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Gan

自引率

0.00%

发文量