胃提物预处理对x射线诱导的ICR小鼠胃肿瘤发生的影响。

Gan Pub Date : 1984-10-01
H Watanabe, M Naito, K Kawashima, A Ito
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引用次数: 0

摘要

研究了胃粗提物(CSE)对x射线诱导胃肿瘤发生的影响。ICR小鼠每隔一周接受两次或四次CSE治疗,然后在最后一次CSE治疗一周后接受20 Gy的x射线照射。出乎意料的是,两次CSE预处理并没有显著改变x射线诱导肿瘤的发生率,但四次CSE预处理却显著降低了x射线诱导肿瘤的发生率。同样,四次CSE预处理显著减少了x射线照射后一周腺胃的糜烂和鳞状化生,而两次CSE预处理则没有。
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The effects of pretreatment with stomach extract on the incidence of X-ray-induced gastric tumor in ICR mice.

The effect of crude stomach extracts (CSE) on X-ray-induced gastric tumorigenesis was examined. ICR mice were treated with two or four administrations of CSE at one-week intervals then irradiated with 20 Gy of X-rays one week after the final CSE administration. Unexpectedly, the incidence of X-ray-induced tumors was not significantly altered by two CSE pretreatments but was markedly reduced by four CSE pretreatments. Similarly, erosion and squamous metaplasia produced in the glandular stomach a week after X-irradiation were markedly diminished by four CSE pretreatments but not by two CSE pretreatments.

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