{"title":"γ辐照诱导共济失调毛细血管扩张性淋巴母细胞样细胞突变。","authors":"K Tatsumi, H Takebe","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Ataxia-telangiectasia (AT) cells are hypersensitive to the lethal effect of gamma-rays, whereas little or no gamma-ray induced mutation has been observed. In this work, exposure to gamma-rays of an Epstein-Barr virus-transformed AT lymphoblastoid cell line, GM2783, resulted in a clear dose-dependent increase of mutation for 6-thioguanine resistance.</p>","PeriodicalId":12660,"journal":{"name":"Gan","volume":"75 12","pages":"1040-3"},"PeriodicalIF":0.0000,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gamma-irradiation induces mutation in ataxia-telangiectasia lymphoblastoid cells.\",\"authors\":\"K Tatsumi, H Takebe\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ataxia-telangiectasia (AT) cells are hypersensitive to the lethal effect of gamma-rays, whereas little or no gamma-ray induced mutation has been observed. In this work, exposure to gamma-rays of an Epstein-Barr virus-transformed AT lymphoblastoid cell line, GM2783, resulted in a clear dose-dependent increase of mutation for 6-thioguanine resistance.</p>\",\"PeriodicalId\":12660,\"journal\":{\"name\":\"Gan\",\"volume\":\"75 12\",\"pages\":\"1040-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gan","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Gamma-irradiation induces mutation in ataxia-telangiectasia lymphoblastoid cells.
Ataxia-telangiectasia (AT) cells are hypersensitive to the lethal effect of gamma-rays, whereas little or no gamma-ray induced mutation has been observed. In this work, exposure to gamma-rays of an Epstein-Barr virus-transformed AT lymphoblastoid cell line, GM2783, resulted in a clear dose-dependent increase of mutation for 6-thioguanine resistance.
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