慢性乙醇给药对小鼠体内脑蛋白分解的影响。

Substance and alcohol actions/misuse Pub Date : 1984-01-01
E Toth, A Lajtha
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引用次数: 0

摘要

通过单次腹腔注射缬氨酸对BALB/cBy小鼠的脑蛋白进行标记,为期8天。然后给小鼠注射10%的乙醇,通过脑蛋白中标签的释放来估计蛋白质的分解。在全脑和脑亚细胞部分(髓磷脂、突触体、线粒体、微粒体和细胞核)中测量,乙醇摄入可显著抑制脑蛋白在体内的分解。连续4.5个月摄入10%乙醇导致氨基酸水平的微小变化;血浆和脑组织中有升高有降低,但多数变化不显著(P > 0.05)。延长乙醇摄入可使脑内AIB的摄取减少17%。
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Effect of chronic ethanol administration on brain protein breakdown in mice in vivo.

Brain proteins of BALB/cBy mice were labeled for a period of 8 days by a single intraperitoneal injection of valine. Following this the mice received 10% ethanol and protein breakdown was estimated from the release of label from brain proteins. Ethanol intake resulted in a significant inhibition of cerebral protein breakdown in vivo as measured in whole brain and in subcellular brain fractions (myelin, synaptosomes, mitochondria, microsomes, and nuclei). The intake of 10% ethanol for 4.5 months resulted in minor alterations in amino acid levels; increase in some and decrease in others were observed in plasma and brain, but most of the changes were not significant (P greater than 0.05). The uptake of AIB in brain was decreased 17% by prolonged ethanol intake.

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