T Sakano, A Hosokawa, N Horino, S Hyodo, T Kishi, T Suzawa, E Kittaka, N Sakura, T Usui
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A case of immunodeficiency with decreased serum IgA levels and impaired polyclonal B cell differentiation in vitro.
We report a patient with low serum IgA levels and persistent pulmonary infection. In spite of the normal contents of serum IgG and IgM, the patient had a deficiency for plasma cell differentiation of all major classes of immunoglobulins (IgG, IgA and IgM). Cross culture systems between normal T or B cells and the patient's T or B cells showed a defect of both T and B cell function.
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