{"title":"恶性疾病患者纤维蛋白肽a (FPA)水平与纤维蛋白原动力学的关系","authors":"Y Yoda, H Nakamura, T Abe","doi":"10.1159/000408457","DOIUrl":null,"url":null,"abstract":"<p><p>The relationship between FPA level and fibrinogen turnover rate as well as fibrinolytic activity was studied in 18 patients with malignant diseases. It was found that the FPA levels were significantly elevated and were correlated with fibrinogen turnover rate (r = 0.74, p less than 0.001) and FDP (r = 0.58, p less than 0.02). The estimated FPA turnover rate was also correlated with fibrinogen turnover rate (r = 0.70, p less than 0.001). These results suggest that fibrinogen catabolism in patients with malignant disease is related to thrombin proteolysis. However, ratios of 1/2 FPA turnover rate to fibrinogen turnover rate suggest that intravascular thrombin proteolysis is not the major determinant of fibrinogen catabolism. It is suspected that extravascular thrombin proteolysis is responsible for the elevation of plasma FPA level which is correlated with acceleration of fibrinogen catabolism.</p>","PeriodicalId":75590,"journal":{"name":"Bibliotheca haematologica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000408457","citationCount":"1","resultStr":"{\"title\":\"Relationship between fibrinopeptide a (FPA) level and fibrinogen kinetics in patients with malignant disease.\",\"authors\":\"Y Yoda, H Nakamura, T Abe\",\"doi\":\"10.1159/000408457\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The relationship between FPA level and fibrinogen turnover rate as well as fibrinolytic activity was studied in 18 patients with malignant diseases. It was found that the FPA levels were significantly elevated and were correlated with fibrinogen turnover rate (r = 0.74, p less than 0.001) and FDP (r = 0.58, p less than 0.02). The estimated FPA turnover rate was also correlated with fibrinogen turnover rate (r = 0.70, p less than 0.001). These results suggest that fibrinogen catabolism in patients with malignant disease is related to thrombin proteolysis. However, ratios of 1/2 FPA turnover rate to fibrinogen turnover rate suggest that intravascular thrombin proteolysis is not the major determinant of fibrinogen catabolism. It is suspected that extravascular thrombin proteolysis is responsible for the elevation of plasma FPA level which is correlated with acceleration of fibrinogen catabolism.</p>\",\"PeriodicalId\":75590,\"journal\":{\"name\":\"Bibliotheca haematologica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000408457\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bibliotheca haematologica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000408457\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bibliotheca haematologica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000408457","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
本文对18例恶性肿瘤患者FPA水平与纤维蛋白原周转率及纤溶活性的关系进行了研究。FPA水平显著升高,并与纤维蛋白原周转率(r = 0.74, p < 0.001)和FDP (r = 0.58, p < 0.02)相关。估计的FPA周转率也与纤维蛋白原周转率相关(r = 0.70, p < 0.001)。这些结果提示恶性疾病患者纤维蛋白原分解代谢与凝血酶蛋白水解有关。然而,1/2 FPA周转率与纤维蛋白原周转率的比值表明,血管内凝血酶蛋白水解并不是纤维蛋白原分解代谢的主要决定因素。推测血管外凝血酶蛋白水解是血浆FPA水平升高的原因,而FPA水平升高与纤维蛋白原分解代谢加速有关。
Relationship between fibrinopeptide a (FPA) level and fibrinogen kinetics in patients with malignant disease.
The relationship between FPA level and fibrinogen turnover rate as well as fibrinolytic activity was studied in 18 patients with malignant diseases. It was found that the FPA levels were significantly elevated and were correlated with fibrinogen turnover rate (r = 0.74, p less than 0.001) and FDP (r = 0.58, p less than 0.02). The estimated FPA turnover rate was also correlated with fibrinogen turnover rate (r = 0.70, p less than 0.001). These results suggest that fibrinogen catabolism in patients with malignant disease is related to thrombin proteolysis. However, ratios of 1/2 FPA turnover rate to fibrinogen turnover rate suggest that intravascular thrombin proteolysis is not the major determinant of fibrinogen catabolism. It is suspected that extravascular thrombin proteolysis is responsible for the elevation of plasma FPA level which is correlated with acceleration of fibrinogen catabolism.