{"title":"通过修饰的还原末端残基，肝素选择性共价结合制备了一种新的非血栓形成表面。","authors":"O Larm, R Larsson, P Olsson","doi":"10.3109/10731198309118804","DOIUrl":null,"url":null,"abstract":"<p><p>A new method for the covalent binding of heparin to artificial surfaces has been developed. The heparinized surface releases insignificant amounts of heparin and can be regarded as stable. The blood contact properties as studied in vitro revealed that the surface was highly thromboresistant in terms of reduced platelet adhesion, surface catalyzed adsorption and inhibition of thrombin and capacity to prevent clotting of nonanticoagulated blood.</p>","PeriodicalId":75597,"journal":{"name":"Biomaterials, medical devices, and artificial organs","volume":"11 2-3","pages":"161-73"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198309118804","citationCount":"430","resultStr":"{\"title\":\"A new non-thrombogenic surface prepared by selective covalent binding of heparin via a modified reducing terminal residue.\",\"authors\":\"O Larm, R Larsson, P Olsson\",\"doi\":\"10.3109/10731198309118804\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A new method for the covalent binding of heparin to artificial surfaces has been developed. The heparinized surface releases insignificant amounts of heparin and can be regarded as stable. The blood contact properties as studied in vitro revealed that the surface was highly thromboresistant in terms of reduced platelet adhesion, surface catalyzed adsorption and inhibition of thrombin and capacity to prevent clotting of nonanticoagulated blood.</p>\",\"PeriodicalId\":75597,\"journal\":{\"name\":\"Biomaterials, medical devices, and artificial organs\",\"volume\":\"11 2-3\",\"pages\":\"161-73\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/10731198309118804\",\"citationCount\":\"430\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomaterials, medical devices, and artificial organs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/10731198309118804\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials, medical devices, and artificial organs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10731198309118804","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A new non-thrombogenic surface prepared by selective covalent binding of heparin via a modified reducing terminal residue.
A new method for the covalent binding of heparin to artificial surfaces has been developed. The heparinized surface releases insignificant amounts of heparin and can be regarded as stable. The blood contact properties as studied in vitro revealed that the surface was highly thromboresistant in terms of reduced platelet adhesion, surface catalyzed adsorption and inhibition of thrombin and capacity to prevent clotting of nonanticoagulated blood.
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