G Barchewitz, F Binon, A Cier, H Tuchmann-Duplessis
{"title":"[苯并呋喃-苯并西平治疗大鼠假瘤性子宫反应]。","authors":"G Barchewitz, F Binon, A Cier, H Tuchmann-Duplessis","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>When orally administered, 5-(3-diméthylamino propyliden)-benzofuro [2,3-c] benzoxepin-1, which antagonizes several biogenic amines, is slightly sedative and has also endocrinological properties in the Rat, induces the appearance of localized lesions of uterine stroma in 2 to 16% of the animals. The cytological picture could suggest a tumorogenesis. In fact, these lesions represent a non-tumoral reactional hyperplasia with nuclear abnormalities due to a hormonal stimulation.</p>","PeriodicalId":10605,"journal":{"name":"Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles","volume":"291 4","pages":"409-11"},"PeriodicalIF":0.0000,"publicationDate":"1980-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Pseudotumoral uterine reaction in the rat treated with a benzofuro-benzoxepin].\",\"authors\":\"G Barchewitz, F Binon, A Cier, H Tuchmann-Duplessis\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>When orally administered, 5-(3-diméthylamino propyliden)-benzofuro [2,3-c] benzoxepin-1, which antagonizes several biogenic amines, is slightly sedative and has also endocrinological properties in the Rat, induces the appearance of localized lesions of uterine stroma in 2 to 16% of the animals. The cytological picture could suggest a tumorogenesis. In fact, these lesions represent a non-tumoral reactional hyperplasia with nuclear abnormalities due to a hormonal stimulation.</p>\",\"PeriodicalId\":10605,\"journal\":{\"name\":\"Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles\",\"volume\":\"291 4\",\"pages\":\"409-11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Pseudotumoral uterine reaction in the rat treated with a benzofuro-benzoxepin].
When orally administered, 5-(3-diméthylamino propyliden)-benzofuro [2,3-c] benzoxepin-1, which antagonizes several biogenic amines, is slightly sedative and has also endocrinological properties in the Rat, induces the appearance of localized lesions of uterine stroma in 2 to 16% of the animals. The cytological picture could suggest a tumorogenesis. In fact, these lesions represent a non-tumoral reactional hyperplasia with nuclear abnormalities due to a hormonal stimulation.
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