氨基酸前体对脑内儿茶酚胺合成的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90048-5

David J. Edwards, Marguerite Rizk

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引用次数: 17

摘要

1.1. 我们利用GC/CI/MS技术研究了左旋多巴、DOPS和酪氨酸作为CAs的前体，以测定这些氨基酸对大鼠大脑和尿液代谢产物产生的影响。左旋多巴引起脑内NE代谢物水平的显著升高，而外周脱羧酶抑制剂Ro4-4602.3.3无法阻断这一过程。DOPS增加了脑内NE和DA代谢物的水平，但Ro4-4602.4.4阻断了NE代谢物(而不是DA)的增加。酪氨酸对脑内CA代谢物无显著影响，但酪胺和章鱼胺代谢物增加了2 ~ 3倍。我们的结论是，用这些前体氨基酸获得的结果的解释可能由于它们缺乏特异性或在脑毛细血管中转化为胺而变得复杂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effects of amino acid precursors on catecholamine synthesis in the brain

1.
1. We studied L-DOPA, DOPS and tyrosine as precursors of CAs using GC/CI/MS techniques to measure the effects of these amino acids in rats on the production of metabolites in brain and urine.
2.
2. L-DOPA caused a significant increase in levels of brain NE metabolites which was not blocked by the peripheral decarboxylase inhibitor, Ro4-4602.
3.
3. DOPS increased brain levels of both NE and DA metabolites but the increases in NE (but not DA) metabolites were blocked by Ro4-4602.
4.
4. Tyrosine had no significant effect on CA metabolites in brain, but metabolites of tyramine and octopamine were increased 2- to 3-fold.
5.
5. We conclude that interpretation of results obtained with these precursor amino acids may be complicated by their lack of specificity or by conversion to amines in the brain capillaries.

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