关于3-羧基茴香醇的脱羧。

Substance and alcohol actions/misuse Pub Date : 1982-01-01

A M Marshall, M Hirst

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引用次数: 0

摘要

以DOPA (1-14C)为原料制备了3-羧基乙醇醇(14C-COOH)。在体外和体内进行了研究，以检查这种氨基酸四氢异喹啉转化为salsolinol的可能性与从其氨基酸前体形成多巴胺的平行方式。结果表明，这种情况并非如此，因为DOPA比3-羧基solinol更容易脱羧。少量的二氧化碳(14C)从3-羧基solinol (14C- cooh)中释放出来，但这可能反映了非酶脱羧。

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Concerning the decarboxylation of 3-carboxysalsolinol.

3-Carboxysalsolinol (14C-COOH) was prepared from DOPA (1-14C). Both in vitro and in vivo studies were conducted to examine the possibility that this amino-acid tetrahydroisoquinoline is converted to salsolinol in a parallel manner to the formation of dopamine from its amino-acid precursor. The results showed that this is not so for DOPA is decarboxylated far more readily than is 3-carboxysalsolinol. Small quantities of carbon dioxide (14C) are liberated from 3-carboxysalsolinol (14C-COOH), but this may reflect non-enzymatic decarboxylation.

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Substance and alcohol actions/misuse

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