[住院抑郁症患者代表性群体的临床特征]。

J Schöpf, J M Gaillard, C Müller, C van Duyse, P K Le
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引用次数: 0

摘要

为了确定住院抑郁症患者的一些主要临床特征,作者检查了一组连续入住洛桑精神病学大学诊所的100名抑郁症患者。该诊所同时也是一家区医院。抑郁症患者占所有住院患者的21%。在研究期间(6个月)收治的抑郁症患者人数可以计算出每10万居民和每年86名患者的住院率。这100例患者被细分为短期抑郁反应、神经性抑郁和内源性抑郁。这三个亚组的大小都差不多。采用改良版icd9进行诊断分类。总体而言,患者表现出严重的精神症状,多数患者有自杀倾向。此外,还发现了一些通常不被认为与抑郁症相关的特征:在整个群体中,未婚者的比例较高,在反应性和神经性抑郁症患者中有精神病态特征,在最后提到的两个亚群体中,在儿童早期失去父母的比例相当大。此外,在神经性抑郁症组中观察到慢性和治疗抵抗病例的积累。三分之一的内源性抑郁症患者对门诊抗抑郁治疗有耐药性;这些病人中有一部分对医院的治疗反应良好。
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[Clinical characteristics of a representative group of hospitalized depressed patients].

In order to define some principal clinical characteristics of the hospitalised depressives, the authors have examined a group of 100 depressed patients consecutively admitted to the Psychiatric University Clinic of Lausanne. The clinic is at the same time a sector hospital. The depressives constituted 21% of all hospitalised patients. The number of depressives admitted during the duration of the study (6 months) permitted to calculate a hospitalisation rate of 86 patients per 100 000 inhabitants and per year. The 100 patients were subclassified in patients with a short depressive reaction, neurotic depressives, and endogenous depressives. Each of the 3 subgroups had about the same size. A modified version of the ICD 9 was used for the diagnostic classification. As a whole, the patients showed serious psychiatric manifestations and the majority presented suicidal tendencies. Besides, there were found characteristics which are not considered to be associated with depressions in general: an elevated proportion of unmarried persons in the total group, psychopathic traits among the reactive and neurotic depressives, and a considerable proportion of parental loss in early childhood in these two last mentioned subgroups. Furthermore, an accumulation of chronic and therapy resistant cases was observed in the group of neurotic depressives. A third of the endogenous depressives had been resistant to the ambulatory antidepressive treatment; a part of these patients responded well to the treatment in the hospital.

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